Journal article
Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors
Cellular and molecular life sciences : CMLS, Vol.73(16), pp.3035-3051
08/2016
DOI: 10.1007/s00018-016-2212-3
PMCID: PMC4956549
PMID: 27032699
Abstract
Nod-like receptors (NLRs) have gained attention in recent years because of the ability of some family members to assemble into a multimeric protein complex known as the inflammasome. The role of NLRs and the inflammasome in regulating innate immunity against bacterial pathogens has been well studied. However, recent studies show that NLRs and inflammasomes also play a role during infections caused by protozoan parasites, which pose a significant global health burden. Herein, we review the diseases caused by the most common protozoan parasites in the world and discuss the roles of NLRs and inflammasomes in host immunity against these parasites.
Details
- Title: Subtitle
- Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors
- Creators
- Prajwal Gurung - Department of Immunology St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis TN 38105-2794 USAThirumala-Devi Kanneganti - Department of Immunology St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis TN 38105-2794 USA
- Resource Type
- Journal article
- Publication Details
- Cellular and molecular life sciences : CMLS, Vol.73(16), pp.3035-3051
- DOI
- 10.1007/s00018-016-2212-3
- PMID
- 27032699
- PMCID
- PMC4956549
- NLM abbreviation
- Cell Mol Life Sci
- ISSN
- 1420-682X
- eISSN
- 1420-9071
- Publisher
- Springer International Publishing
- Grant note
- AR056296; CA163507; AI101935 / National Institutes of Health (US) (http://dx.doi.org/10.13039/100000002)
- Language
- English
- Date published
- 08/2016
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094582602771
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