Journal article
Immune responses in the mammalian inner ear and their implications for AAV-me diate d inner ear gene therapy
Hearing research, Vol.432, 108735
05/01/2023
DOI: 10.1016/j.heares.2023.108735
PMID: 36965335
Abstract
Adeno-associated virus (AAV)-mediated inner ear gene therapy is a promising treatment option for hear-ing loss and dizziness. Several studies have shown that AAV-mediated inner ear gene therapy can be applied to various mouse models of hereditary hearing loss to improve their auditory function. Despite the increase in AAV-based animal and clinical studies aiming to rescue auditory and vestibular functions, little is currently known about the host immune responses to AAV in the mammalian inner ear. It has been reported that the host immune response plays an important role in the safety and efficacy of viral -mediated gene therapy. Therefore, in order for AAV-mediated gene therapy to be successfully and safely translated into patients with hearing loss and dizziness, a better understanding of the host immune re-sponses to AAV in the inner ear is critical. In this review, we summarize the current knowledge on host immune responses to AAV-mediated gene therapy in the mammalian inner ear and other organ systems. We also outline the areas of research that are critical for ensuring the safety and efficacy of AAV-mediated inner ear gene therapy in future clinical and translational studies. (c) 2023 Published by Elsevier B.V.
Details
- Title: Subtitle
- Immune responses in the mammalian inner ear and their implications for AAV-me diate d inner ear gene therapy
- Creators
- Yasuko Ishibashi - National Institute on Deafness and Other Communication DisordersCathy Yea Won Sung - National Institute on Deafness and Other Communication DisordersMhamed Grati - Natl Inst Deafness & Other Commun Disorders NIDCD, Inner Ear Gene Therapy Program, NIH, 35A 1F220,35A Covent Dr, Bethesda, MD 20892 USAWade Chien - National Institute on Deafness and Other Communication Disorders
- Resource Type
- Journal article
- Publication Details
- Hearing research, Vol.432, 108735
- DOI
- 10.1016/j.heares.2023.108735
- PMID
- 36965335
- NLM abbreviation
- Hear Res
- ISSN
- 0378-5955
- eISSN
- 1878-5891
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- DC000082-02; DC000079 / NIDCD Division of Intramural Research grants
- Language
- English
- Date published
- 05/01/2023
- Academic Unit
- Biology
- Record Identifier
- 9984961047602771
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