Immunity to varicella-zoster viral glycoproteins, gp I (gp 90/58) and gp III (gp 118), and to a nonglycosylated protein, p 170

Ann M Arvin; Elaine Kinney-Thomas; Kathy Shriver; Charles Grose; Celine M Koropchak; Elizabeth Scranton; Alec E Wittek; Pamela S Diaz

doi:10.4049/jimmunol.137.4.1346

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Immunity to varicella-zoster viral glycoproteins, gp I (gp 90/58) and gp III (gp 118), and to a nonglycosylated protein, p 170

Journal article

Peer reviewed

Immunity to varicella-zoster viral glycoproteins, gp I (gp 90/58) and gp III (gp 118), and to a nonglycosylated protein, p 170

Ann M Arvin, Elaine Kinney-Thomas, Kathy Shriver, Charles Grose, Celine M Koropchak, Elizabeth Scranton, Alec E Wittek and Pamela S Diaz

The Journal of immunology (1950), Vol.137(4), pp.1346-1351

1986

DOI: 10.4049/jimmunol.137.4.1346

PMID: 3016094

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Abstract

Humoral and cellular immunity against two major glycoproteins (gp) of varicella-zoster virus (VZV), gp I (gp 90/58) and gp III (gp 118), and against a nonglycosylated phosphoprotein (p 170) was demonstrated in human subjects. Primary VZV infection was accompanied by the development of IgG to gp I (mean titer 1:200), gp III (mean titer 1:132), and p 170 (mean titer 1:331). Increased IgG antibody production to each of the VZV proteins occurred during recurrent VZV infection with mean titers to gp I of 1:29512, to gp III of 1:15848, and to p 170 of 1:15848. Persistent high titers to gp III (mean titer 1:891) and to p 170 (mean titer 1:2238) were observed in 75% and 88% of VZV-immune subjects, respectively. T lymphocytes which proliferated on stimulation with gp I, gp III, and p 170 developed with primary VZV infection. VZV-immune subjects had mean transformation indices of 4.2 +/- 0.70 SE to gp I, 4.7 +/- 1 SE to gp III, and 3 +/- 0.39 SE to p 170. Among individual subjects, humoral and cellular immunity was not always detected to all three of the VZV proteins. Resolution of primary VZV infection and maintenance of VZV latency did not require a host response to each of these major viral proteins.

Immunobiology

Fundamental and applied biological sciences. Psychology

Fundamental immunology

Biological and medical sciences

Organs and cells involved in the immune response

Analysis of the immune response. Humoral and cellular immunity

Details

Title: Subtitle: Immunity to varicella-zoster viral glycoproteins, gp I (gp 90/58) and gp III (gp 118), and to a nonglycosylated protein, p 170
Creators: Ann M Arvin - Stanford univ., school medicine, Stanford CA 94305, United States
Elaine Kinney-Thomas - Stanford univ., school medicine, Stanford CA 94305, United States
Kathy Shriver - Stanford univ., school medicine, Stanford CA 94305, United States
Charles Grose - Stanford univ., school medicine, Stanford CA 94305, United States
Celine M Koropchak - Stanford univ., school medicine, Stanford CA 94305, United States
Elizabeth Scranton - Stanford univ., school medicine, Stanford CA 94305, United States
Alec E Wittek - Stanford univ., school medicine, Stanford CA 94305, United States
Pamela S Diaz - Stanford univ., school medicine, Stanford CA 94305, United States
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.137(4), pp.1346-1351
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.137.4.1346
PMID: 3016094
ISSN: 0022-1767
eISSN: 1550-6606
Language: English
Date published: 1986
Academic Unit: Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
Record Identifier: 9984093489902771

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