Journal article
Immunization of inbred guinea pigs with varicella-zoster virus grown in a syngeneic transformed embryo cell line
Journal of clinical microbiology, Vol.14(2), pp.229-231
08/1981
DOI: 10.1128/JCM.14.2.229-231.1981
PMCID: PMC271940
PMID: 6268659
Abstract
Varicella-zoster virus was serially propagated in a chemically transformed and cloned line of embryo cells (designated "104 C1") derived from the inbred strain 2 guinea pig. When strain 2 guinea pigs were immunized with varicella-zoster virus subcultivated in the syngeneic cell line, they produced high-titer virus-specific antiserum which lacked antibody against cellular determinants. This immunization procedure offers both practical and theoretical advantages over prior methods which involved inoculation of outbred laboratory animals with varicella-zoster virus grown in allogeneic or xenogeneic cell cultures.
Details
- Title: Subtitle
- Immunization of inbred guinea pigs with varicella-zoster virus grown in a syngeneic transformed embryo cell line
- Creators
- C Grose
- Resource Type
- Journal article
- Publication Details
- Journal of clinical microbiology, Vol.14(2), pp.229-231
- DOI
- 10.1128/JCM.14.2.229-231.1981
- PMID
- 6268659
- PMCID
- PMC271940
- ISSN
- 0095-1137
- eISSN
- 1098-660X
- Grant note
- AI 14604 / NIAID NIH HHS
- Language
- English
- Date published
- 08/1981
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093469902771
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