Immunogenicity of a Two Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial

Nadine G Rouphael; Angela R Branche; David J Diemert; Ann R Falsey; Cecilia Losada; Lindsey R Baden; Sharon E Frey; Jennifer A Whitaker; Susan J Little; Satoshi Kamidani; Emmanuel B Walter; Richard M Novak; Richard Rupp; Lisa A Jackson; Tara M Babu; Angelica C Kottkamp; Anne F Luetkemeyer; Lilly C Immergluck; Rachel M Presti; Martín Bäcker; Patricia L Winokur; Siham M Mahgoub; Paul A Goepfert; Dahlene N Fusco; Robert L Atmar; Christine M Posavad; Antonia Netzl; Derek J Smith; Kalyani Telu; Jinjian Mu; Lisa J McQuarrie; Mat Makowski; Mamodikoe K Makhene; Sonja Crandon; David C Montefiori; Paul C Roberts; John H Beigel

doi:10.1093/infdis/jiad323

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Immunogenicity of a Two Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial

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Immunogenicity of a Two Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial

Nadine G Rouphael, Angela R Branche, David J Diemert, Ann R Falsey, Cecilia Losada, Lindsey R Baden, Sharon E Frey, Jennifer A Whitaker, Susan J Little, Satoshi Kamidani, …

The Journal of infectious diseases, Vol.228(12), pp.1662-1666

12/20/2023

DOI: 10.1093/infdis/jiad323

PMCID: PMC11032204

PMID: 37561027

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Abstract

We compared the serologic responses of one versus two doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A two-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.

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Title: Subtitle: Immunogenicity of a Two Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial
Creators: Nadine G Rouphael
Angela R Branche
David J Diemert
Ann R Falsey
Cecilia Losada
Lindsey R Baden
Sharon E Frey
Jennifer A Whitaker
Susan J Little
Satoshi Kamidani
Emmanuel B Walter
Richard M Novak
Richard Rupp
Lisa A Jackson
Tara M Babu
Angelica C Kottkamp
Anne F Luetkemeyer
Lilly C Immergluck
Rachel M Presti
Martín Bäcker
Patricia L Winokur
Siham M Mahgoub
Paul A Goepfert
Dahlene N Fusco
Robert L Atmar
Christine M Posavad
Antonia Netzl
Derek J Smith
Kalyani Telu
Jinjian Mu
Lisa J McQuarrie
Mat Makowski
Mamodikoe K Makhene
Sonja Crandon
David C Montefiori
Paul C Roberts
John H Beigel
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.228(12), pp.1662-1666
DOI: 10.1093/infdis/jiad323
PMID: 37561027
PMCID: PMC11032204
NLM abbreviation: J Infect Dis
eISSN: 1537-6613
Grant note: DOI: 10.13039/100000054, name: National Cancer Institute; DOI: 10.13039/100000002, name: National Institutes of Health, award: 75N91019D00024, 75N91022F00007; DOI: 10.13039/100015691, name: Division of Microbiology and Infectious Diseases, award: 75N93021C00012; name: Office of the Assistant Secretary for Preparedness and Response; DOI: 10.13039/100012399, name: Biomedical Advanced Research and Development Authority, award: 75A50122C00008; DOI: 10.13039/100000002, name: NIH, award: 75N93021C00014, R01AI165818; DOI: 10.13039/100000016, name: Department of Health and Human Services; name: US government
Language: English
Electronic publication date: 08/10/2023
Date published: 12/20/2023
Academic Unit: Infectious Diseases; Medicine Administration; Internal Medicine
Record Identifier: 9984453200602771

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