Journal article
Immunogenicity of the BA.1 and BA.4/BA.5 SARS-CoV-2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial
Clinical infectious diseases, Vol.77(4), pp.560-564
08/15/2023
DOI: 10.1093/cid/ciad209
PMCID: PMC10443997
PMID: 37036397
Abstract
In a randomized clinical trial, we compare early neutralizing antibody responses after boosting with bivalent SARS-CoV-2 mRNA vaccines based on either BA.1 or BA.4/BA.5 Omicron spike protein combined with wildtype spike. Responses against SARS-CoV-2 variants exhibited the greatest reduction in titers against currently circulating Omicron subvariants for both bivalent vaccines.
Details
- Title: Subtitle
- Immunogenicity of the BA.1 and BA.4/BA.5 SARS-CoV-2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial
- Creators
- Angela R Branche - University of RochesterNadine G Rouphael - HOPE ClinicCecilia Losada - HOPE ClinicLindsey R Baden - Brigham and Women's HospitalEvan J Anderson - Emory UniversityAnne F Luetkemeyer - University of California, San FranciscoDavid J Diemert - George Washington UniversityPatricia L Winokur - University of IowaRachel M Presti - Washington University in St. LouisAngelica C Kottkamp - Manhattan Psychiatric CenterAnn R Falsey - University of RochesterSharon E Frey - Saint Louis UniversityRichard Rupp - The University of Texas Medical Branch at GalvestonMartín Bäcker - Long Island UniversityRichard M Novak - University of Illinois ChicagoEmmanuel B Walter - Duke UniversityLisa A Jackson - Kaiser Permanente Washington Health Research InstituteSusan J Little - University of California San DiegoLilly C Immergluck - Morehouse School of MedicineSiham M Mahgoub - Howard University HospitalJennifer A Whitaker - Baylor College of MedicineTara M Babu - Fred Hutch Cancer CenterPaul A Goepfert - University of Alabama at BirminghamDahlene N Fusco - Tulane UniversityRobert L Atmar - Baylor College of MedicineChristine M Posavad - Fred Hutch Cancer CenterAntonia Netzl - University of CambridgeDerek J Smith - University of CambridgeKalyani Telu - Emmes (United States)Jinjian Mu - Emmes (United States)Mat Makowski - Emmes (United States)Mamodikoe K Makhene - National Institute of Allergy and Infectious DiseasesSonja Crandon - National Institute of Allergy and Infectious DiseasesDavid C Montefiori - Duke UniversityPaul C Roberts - National Institute of Allergy and Infectious DiseasesJohn H Beigel - National Institutes of Health
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.77(4), pp.560-564
- DOI
- 10.1093/cid/ciad209
- PMID
- 37036397
- PMCID
- PMC10443997
- NLM abbreviation
- Clin Infect Dis
- eISSN
- 1537-6591
- Grant note
- DOI: 10.13039/100000054, name: National Cancer Institute; DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000016, name: Department of Health and Human Services
- Language
- English
- Electronic publication date
- 04/10/2023
- Date published
- 08/15/2023
- Academic Unit
- Infectious Diseases; Medicine Administration; Internal Medicine
- Record Identifier
- 9984388756402771
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