Journal article
Immunoglobulin E as a Biomarker for the Overlap of Atopic Asthma and Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary diseases, Vol.7(1), pp.1-12
01/2020
DOI: 10.15326/jcopdf.7.1.2019.0138
PMCID: PMC7182380
PMID: 31999898
Abstract
Asthma-COPD overlap (ACO) is a common clinical syndrome, yet there is no single objective definition. We hypothesized that immunoglobulin E (IgE) measurements could be used to refine the definition of ACO. In baseline plasma samples from 2870 participants in the COPD Genetic Epidemiology (COPDGene®) study, we measured total IgE levels and specific IgE levels to 6 common allergens. Compared to usual chronic obstructive pulmonary disease (COPD), participants with ACO (based on self-report of asthma) had higher total IgE levels (median 67.0 versus 42.2 IU/ml) and more frequently had at least one positive specific IgE (43.5% versus 24.5%). We previously used a strict definition of ACO in participants with COPD, based on self-report of a doctor's diagnosis of asthma before age 40. This strict ACO definition was refined by the presence of atopy, determined by total IgE > 100 IU/ml or at least one positive specific IgE, as was the broader definition of ACO based on self-reported asthma history. Participants with all 3 ACO definitions were younger (mean age 60.0-61.3 years), were more commonly African American (36.8%-44.2%), had a higher exacerbation frequency (1.0-1.2 in the past year), and had more airway wall thickening on quantitative analysis of chest computed tomography (CT) scans. Among participants with ACO, 37%-46% did not have atopy; these individuals had more emphysema on chest CT scan. Based on associations with exacerbations and CT airway disease, IgE did not clearly improve the clinical definition of ACO. However, IgE measurements could be used to subdivide individuals with atopic and non-atopic ACO, who might have different biologic mechanisms and potential treatments.
Details
- Title: Subtitle
- Immunoglobulin E as a Biomarker for the Overlap of Atopic Asthma and Chronic Obstructive Pulmonary Disease
- Creators
- Craig P Hersh - Brigham and Women's HospitalSoumya Zacharia - Brigham and Women's HospitalRam Prakash Arivu Chelvan - Brigham and Women's HospitalLystra P Hayden - Brigham and Women's HospitalAli Mirtar - Biotech (Brazil)Sara Zarei - Biotech (Brazil)Nirupama Putcha - Johns Hopkins UniversityCOPDGene® Investigators
- Contributors
- Karin F Hoth (Contributor) - University of Iowa, Psychiatry
- Resource Type
- Journal article
- Publication Details
- Chronic obstructive pulmonary diseases, Vol.7(1), pp.1-12
- DOI
- 10.15326/jcopdf.7.1.2019.0138
- PMID
- 31999898
- PMCID
- PMC7182380
- NLM abbreviation
- Chronic Obstr Pulm Dis
- ISSN
- 2372-952X
- eISSN
- 2372-952X
- Grant note
- U01 HL089897 / NHLBI NIH HHS R01 HL125583 / NHLBI NIH HHS P01HL132825 / NIH HHS R01HL125583 / NIH HHS COPD Foundation Industry Advisory Committee Novartis U01HL089897 / NIH HHS R01 HL130512 / NHLBI NIH HHS U01 HL089856 / NHLBI NIH HHS K23HL123594 / NIH HHS R01HL130512 / NIH HHS P01 HL132825 / NHLBI NIH HHS K23 HL123594 / NHLBI NIH HHS U01HL089856 / NIH HHS
- Language
- English
- Date published
- 01/2020
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984293755702771
Metrics
14 Record Views