Journal article
Immunohistochemical characterization of antioxidant enzymes in human breast cancer
Pathology oncology research, Vol.3(4), pp.278-286
12/1997
DOI: 10.1007/BF02904287
PMID: 11173648
Abstract
Intrinsic antioxidant enzymes (AE) are essential for protection against potential cellular damage by free radicals (FRs), which affect a variety of biological processes. The levels or activities of AEs can be abnormal in human malignancies in general, and FR production is a possible mechanism of estrogen related carcinogenesis specifically. However, the role of AEs in breast cancer ramains unclear. Immunodetectable AEs were characterized in 95 node negative cancers using rabbit polyclonal antibodies. Results were correlated with established and experimental biomarkers of breast cancer. AEs were greater than benign differentiated epithelium in more than 40% and lower in 10–14% of tumors. Patterns of staining were enzyme and tumor pattern specific. Increased immunodetectable AE was associated with large, poorly differentiated tumors, and younger age. Catalase correlated with nuclear grade and disease related death (pτ; 0.05), and highlighted tumor microvasculature. Additional work in this area may further elucidate the role of AEs in breast cancer growth and progression.
Details
- Title: Subtitle
- Immunohistochemical characterization of antioxidant enzymes in human breast cancer
- Creators
- Patricia Thomas - Department of Pathology and the Radiation Research Laboratory University of Iowa Hospitals and Clinics Iowa City USADilek Oykutlu - Department of Pathology and the Radiation Research Laboratory University of Iowa Hospitals and Clinics Iowa City USABel Pou - Department of Pathology and the Radiation Research Laboratory University of Iowa Hospitals and Clinics Iowa City USADenise Tyler - Department of Pathology and the Radiation Research Laboratory University of Iowa Hospitals and Clinics Iowa City USALarry Oberley - Department of Pathology and the Radiation Research Laboratory University of Iowa Hospitals and Clinics Iowa City USARobert Robinson - Department of Pathology and the Radiation Research Laboratory University of Iowa Hospitals and Clinics Iowa City USAJulia Lenel - Department of Pathology and the Radiation Research Laboratory University of Iowa Hospitals and Clinics Iowa City USA
- Resource Type
- Journal article
- Publication Details
- Pathology oncology research, Vol.3(4), pp.278-286
- Publisher
- Springer Netherlands; Dordrecht
- DOI
- 10.1007/BF02904287
- PMID
- 11173648
- ISSN
- 1219-4956
- eISSN
- 1532-2807
- Language
- English
- Date published
- 12/1997
- Academic Unit
- Oral Pathology, Radiology and Medicine; Pathology
- Record Identifier
- 9984047674802771
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