Journal article
Immunohistochemical expression of MYB in salivary gland basal cell adenocarcinoma and basal cell adenoma
Journal of oral pathology & medicine, Vol.46(9), pp.798-802
10/2017
DOI: 10.1111/jop.12617
PMID: 28727172
Abstract
Background
Basal cell predominant salivary gland neoplasms can be difficult to separate histologically. One of the most aggressive of basaloid salivary gland neoplasms is adenoid cystic carcinoma. MYB expression by immunohistochemistry has been documented in adenoid cystic carcinoma. Some investigators have suggested that using this expression can help in establishing the diagnosis of adenoid cystic carcinoma. Utilizing tissue microarrays, we studied a group of basal cell adenocarcinomas and basal cell adenomas to determine: (i) whether either tumor expressed MYB and (ii) the frequency of any expression in either tumors.
Methods
Seventeen salivary gland basal cell adenocarcinomas and 30 salivary gland basal cell adenomas were used to construct microarrays. These tissue microarrays were used to assess for immunohistochemical MYB expression.
Results
Fifty‐three percent (nine of 17) of salivary gland basal cell adenocarcinomas and 57% (17 of 30) of salivary gland basal cell adenomas showed MYB overexpression. For comparison, we studied 11 adenoid cystic carcinomas for MYB expression and found that 64% (seven of 11) overexpressed MYB. We found no relation to clinical course for basal adenomas or basal cell adenocarcinomas that overexpressed MYB vs those that did not.
Conclusions
MYB expression does not help separate basal cell adenocarcinomas from basal cell adenomas, and our data suggest it does not differentiate between either of these neoplasms and adenoid cystic carcinoma.
Details
- Title: Subtitle
- Immunohistochemical expression of MYB in salivary gland basal cell adenocarcinoma and basal cell adenoma
- Creators
- Sydney L Rooney - University of IowaRobert A Robinson - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of oral pathology & medicine, Vol.46(9), pp.798-802
- DOI
- 10.1111/jop.12617
- PMID
- 28727172
- ISSN
- 0904-2512
- eISSN
- 1600-0714
- Number of pages
- 5
- Grant note
- Department of Pathology, University of Iowa, Iowa City, Iowa
- Language
- English
- Date published
- 10/2017
- Academic Unit
- Oral Pathology, Radiology and Medicine; Pathology
- Record Identifier
- 9984047667802771
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