Journal article
Immunohistochemical localization of TGF-B1 during morphogenetic movements of the developing mouse palate
Journal of craniofacial genetics and developmental biology, Vol.11(3), pp.138-145
07/1991
PMID: 1761646
Abstract
Transforming growth factor-beta (TGF-B1) may play an important role in developmentally active tissues in which it is found in high concentrations. We localized TGF-B1 in the developing fetal mouse palate immunohistochemically using a polyclonal antibody. Mouse fetal palates at 12-17 days (inclusive) of gestation were examined and specific focal concentrations of TGF-B1 identified regions undergoing active morphogenesis. The association of TGF-B1 with aggregates of mesenchymal cells in the palate and chondroblasts, rhabdomyocytes, and epithelia of the craniofacial complex strongly implicates its role in proliferation and differentiation in the developing mouse palate. We believe these findings have important bearing on the normal development of the palate as well as cleft anomalies.
Details
- Title: Subtitle
- Immunohistochemical localization of TGF-B1 during morphogenetic movements of the developing mouse palate
- Creators
- J M Williams - Department of Otolaryngology, Head and Neck Surgery, Iowa City 52242R A RobinsonM Solursh
- Resource Type
- Journal article
- Publication Details
- Journal of craniofacial genetics and developmental biology, Vol.11(3), pp.138-145
- Publisher
- Denmark
- PMID
- 1761646
- ISSN
- 0270-4145
- Language
- English
- Date published
- 07/1991
- Academic Unit
- Oral Pathology, Radiology and Medicine; Pathology; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984047894102771
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