Journal article
Immunologic Considerations for Generating Memory CD8 T Cells through Vaccination
Cellular microbiology, Vol.13(7), pp.925-933
07/2011
DOI: 10.1111/j.1462-5822.2011.01594.x
PMCID: PMC3116979
PMID: 21501363
Abstract
Following infection or vaccination, naïve CD8 T cells that receive the appropriate integration of antigenic, co-stimulatory, and inflammatory signals undergo a programmed series of biological changes that ultimately results in the generation of memory cells. Memory CD8 T cells, in contrast to naïve cells, more effectively limit or prevent pathogen re-infection due to both qualitative and quantitative changes that occur following their induction. Unlike vaccination strategies aimed at generating antibody production, the ability to generate protective memory CD8 T cells has proven more complicated and problematic. However, recent experimental results have revealed important principles regarding the molecular and genetic basis for memory CD8 T cell formation, as well as identified ways to manipulate their development through vaccination, resulting in potential new avenues to enhance protective immunity.
Details
- Title: Subtitle
- Immunologic Considerations for Generating Memory CD8 T Cells through Vaccination
- Creators
- Noah S Butler - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242Jeffrey C Nolz - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242John T Harty - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242
- Resource Type
- Journal article
- Publication Details
- Cellular microbiology, Vol.13(7), pp.925-933
- DOI
- 10.1111/j.1462-5822.2011.01594.x
- PMID
- 21501363
- PMCID
- PMC3116979
- NLM abbreviation
- Cell Microbiol
- ISSN
- 1462-5814
- eISSN
- 1462-5822
- Grant note
- R01 AI059752-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI050073-10 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R37 AI042767-13 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI046653-10 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI085515-02 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
- Language
- English
- Date published
- 07/2011
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984001217802771
Metrics
28 Record Views