Journal article
Immunologic and Molecular Mechanisms in Inflammatory Bowel Disease
The Surgical clinics of North America, Vol.87(3), pp.681-696
2007
DOI: 10.1016/j.suc.2007.03.005
PMID: 17560420
Abstract
Molecular and immunologic mechanisms underlying inflammation in inflammatory bowel disease (IBD) are largely unknown. Recent studies have helped better characterize genetic and environmental factors associated with colitis. Discoveries of genetic variants have confirmed that IBD is a bacteria and cytokine-driven pathologic immune response. Data have demonstrated that certain T cell subsets are important in executing the inflammatory cascade. Insufficient regulatory cell activity or modulatory cytokine production results in unrestrained inflammation. Biologic agents that block inflammatory cytokines (anti-TNFα antibodies) have been used successfully to treat IBD. Recent advances have also identified mucosal regulatory pathways.
Details
- Title: Subtitle
- Immunologic and Molecular Mechanisms in Inflammatory Bowel Disease
- Creators
- M. Nedim InceDavid E Elliott
- Resource Type
- Journal article
- Publication Details
- The Surgical clinics of North America, Vol.87(3), pp.681-696
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.suc.2007.03.005
- PMID
- 17560420
- ISSN
- 0039-6109
- eISSN
- 1558-3171
- Language
- English
- Date published
- 2007
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094394102771
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