Journal article
Immunological monitoring in workers occupationally exposed to asbestos
Toxicology (Amsterdam), Vol.206(2), pp.299-308
2005
DOI: 10.1016/j.tox.2004.09.004
PMID: 15588921
Abstract
Occupational exposure to asbestos is strongly associated with pulmonary diseases, cancer and immunotoxic effects. Both systemic and local immunity may play an important role in the pathogenesis of these events. Immune cells appear to be influenced by asbestos exposure, either through direct effects or as a result of the host's protective response to exposure.
In this study several immune system parameters were assessed in workers (
n
=
61) with at least 5 years’ exposure to asbestos at an industrial plant. Workers exposed to asbestos fibres had significantly increased levels of immunoglobulin E and concentrations of interleukin-6 and -8 in comparison with two sets of controls (in-plant and town control groups). The levels of soluble adhesion molecule ICAM-1 were higher in the exposed group compared to the town control group. Significantly increased levels of IgA were found in asbestos-exposed group in comparison to the town control. Evaluation of the expression of adhesion molecules on lymphocytes, monocytes and granulocytes by flow cytometry showed significant increases in the class of selectins CD62L on monocytes and granulocytes. Moreover, significantly increased expression of markers CD69 and CD66b on eosinophils was found among workers exposed to asbestos. In conclusion, exposure to asbestos fibres was found to have several effects on immune system. Alterations of these immune parameters may indicate hypersensitivity (increased levels of IgE, increased expression of activation markers CD66b and CD69 on eosinophils) and an elevated inflammatory status (increased levels of interleukins—IL-6, IL-8) in exposed workers.
Details
- Title: Subtitle
- Immunological monitoring in workers occupationally exposed to asbestos
- Creators
- Silvia Ilavská - Slovak Medical UniversityEva Jahnová - Slovak Medical UniversityJana Tulinská - Slovak Medical UniversityMira Horváthová - Slovak Medical UniversityMária Dušinská - Slovak Medical UniversityLadislava Wsolová - Slovak Medical UniversitySoterios A. Kyrtopoulos - National Hellenic Research FoundationLaurence Fuortes - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Toxicology (Amsterdam), Vol.206(2), pp.299-308
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/j.tox.2004.09.004
- PMID
- 15588921
- ISSN
- 0300-483X
- eISSN
- 1879-3185
- Language
- English
- Date published
- 2005
- Academic Unit
- Occupational and Environmental Health; Internal Medicine
- Record Identifier
- 9984364410402771
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