Immunology. Long live the mature B cell--a baffling mystery resolved

T J Waldschmidt; R J Noelle

doi:10.1126/science.1065591

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Immunology. Long live the mature B cell--a baffling mystery resolved

Journal article

Peer reviewed

Immunology. Long live the mature B cell--a baffling mystery resolved

T J Waldschmidt and R J Noelle

Science (American Association for the Advancement of Science), Vol.293(5537), pp.2012-2013

09/14/2001

DOI: 10.1126/science.1065591

PMID: 11557866

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Abstract

What determines whether transitional B cells newly emerged from the bone marrow will differentiate further to become mature, long-lived, circulating B lymphocytes? In a Perspective, Waldschmidt and Noelle discuss new findings showing that the TNF family ligand BAFF and its receptor BAFF-R are crucial for selecting transitional B cells into the mature B cell pool (Thompson et al., Schiemann et al.).

Receptors, Tumor Necrosis Factor - metabolism

Tumor Necrosis Factor-alpha - metabolism

Spleen - immunology

Signal Transduction

Cell Survival

Mice, Inbred A

B-Lymphocytes - physiology

Spleen - cytology

Transmembrane Activator and CAML Interactor Protein

Mice, Knockout

B-Cell Activation Factor Receptor

B-Cell Maturation Antigen

Animals

B-Cell Activating Factor

B-Lymphocytes - immunology

Bone Marrow Cells

Mice, Mutant Strains

Ligands

Membrane Proteins - metabolism

Mice

B-Lymphocytes - metabolism

Immunoglobulin M - biosynthesis

Receptors, Tumor Necrosis Factor - genetics

Details

Title: Subtitle: Immunology. Long live the mature B cell--a baffling mystery resolved
Creators: T J Waldschmidt - Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
R J Noelle
Resource Type: Journal article
Publication Details: Science (American Association for the Advancement of Science), Vol.293(5537), pp.2012-2013
Publisher: United States
DOI: 10.1126/science.1065591
PMID: 11557866
ISSN: 0036-8075
eISSN: 1095-9203
Language: English
Date published: 09/14/2001
Academic Unit: Pathology
Record Identifier: 9984047896302771

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