Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy

Xin Lian; Kailin Yang; Renliang Li; Maomao Li; Jing Zuo; Bohao Zheng; Wei Wang; Ping Wang; Shengtao Zhou

doi:10.1186/s12943-021-01486-5

Back

Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy

Journal article

Open access

Peer reviewed

Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy

Xin Lian, Kailin Yang, Renliang Li, Maomao Li, Jing Zuo, Bohao Zheng, Wei Wang, Ping Wang and Shengtao Zhou

Molecular cancer, Vol.21(1), pp.27-27

01/21/2022

DOI: 10.1186/s12943-021-01486-5

PMCID: PMC8780708

PMID: 35062950

Files and links (1)

url

https://doi.org/10.1186/s12943-021-01486-5View

Published (Version of record) Open Access

Abstract

Cellular metabolism constitutes a fundamental process in biology. During tumor initiation and progression, each cellular component in the cancerous niche undergoes dramatic metabolic reprogramming, adapting to a challenging microenvironment of hypoxia, nutrient deprivation, and other stresses. While the metabolic hallmarks of cancer have been extensively studied, the metabolic states of the immune cells are less well elucidated. Here we review the metabolic disturbance and fitness of the immune system in the tumor microenvironment (TME), focusing on the impact of oncometabolites to the function of immune cells and the clinical significance of targeting metabolism in anti-tumor immunotherapy. Metabolic alterations in the immune system of TME offer novel therapeutic insight into cancer treatment.

Adaptation, Biological

Animals

Cell Transformation, Neoplastic - genetics

Cell Transformation, Neoplastic - immunology

Cell Transformation, Neoplastic - metabolism

Cellular Reprogramming

Combined Modality Therapy

Disease Management

Disease Susceptibility

Energy Metabolism

Humans

Immune System - immunology

Immune System - metabolism

Immunomodulation

Immunotherapy

Neoplasms - diagnosis

Neoplasms - etiology

Neoplasms - metabolism

Neoplasms - therapy

Treatment Outcome

Tumor Microenvironment - immunology

Details

Title: Subtitle: Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
Creators: Xin Lian - Sichuan University
Kailin Yang - Cleveland Clinic
Renliang Li - Sichuan University
Maomao Li - Sichuan University
Jing Zuo - West China Medical Center of Sichuan University
Bohao Zheng - Sichuan University
Wei Wang - Sichuan University
Ping Wang - Sichuan University
Shengtao Zhou - Sichuan University
Resource Type: Journal article
Publication Details: Molecular cancer, Vol.21(1), pp.27-27
DOI: 10.1186/s12943-021-01486-5
PMID: 35062950
PMCID: PMC8780708
ISSN: 1476-4598
eISSN: 1476-4598
Grant note: T32 CA094186 / NCI NIH HHS
Language: English
Date published: 01/21/2022
Academic Unit: Radiation Oncology
Record Identifier: 9984696568402771

Metrics

3 Record Views

70 Times Cited - Web of Science

See more details