Immunometabolism in the Aging Heart

Kranti A Mapuskar; Barry London; Zeb R Zacharias; Jon C D Houtman; Bryan G Allen

doi:10.1161/JAHA.124.039216

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Journal article

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Immunometabolism in the Aging Heart

Kranti A Mapuskar, Barry London, Zeb R Zacharias, Jon C D Houtman and Bryan G Allen

Journal of the American Heart Association, Vol.14(1), e039216

01/07/2025

DOI: 10.1161/JAHA.124.039216

PMCID: PMC12054428

PMID: 39719411

Appears in UI Libraries Support Open Access

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Abstract

Structural, functional, and molecular-level changes in the aging heart are influenced by a dynamic interplay between immune signaling and cellular metabolism that is referred to as immunometabolism. This review explores the crosstalk between cellular metabolic pathways including glycolysis, oxidative phosphorylation, fatty acid metabolism, and the immune processes that govern cardiac aging. With a rapidly aging population that coincides with increased cardiovascular risk and cancer incidence rates, understanding the immunometabolic underpinnings of cardiac aging provides a foundation for identifying therapeutic targets to mitigate cardiac dysfunction. Aging alters the immune environment of the heart by concomitantly driving the changes in immune cell metabolism, mitochondrial dysfunction, and redox signaling. Shifts in these metabolic pathways exacerbate inflammation and impair tissue repair, creating a vicious cycle that accelerates cardiac functional decline. Treatment with cancer therapy further complicates this landscape, as aging-associated immunometabolic disruptions augment the susceptibility to cardiotoxicity. The current review highlights therapeutic strategies that target the immunometabolic axis to alleviate cardiac aging pathologies. Interventions include modulating metabolic intermediates, improving mitochondrial function, and leveraging immune signaling pathways to restore cardiac health. Advances in immunometabolism thus hold significant potential for translating preclinical findings into therapies that improve the quality of life for the aging population and underscore the need for approaches that address the immunometabolic mechanisms of cardiac aging, providing a framework for future research.

inflammaging

immunometabolism

cardiac aging

oxidative phosphorylation

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Details

Title: Subtitle: Immunometabolism in the Aging Heart
Creators: Kranti A Mapuskar - University of Iowa
Barry London - University of Iowa
Zeb R Zacharias - University of Iowa
Jon C D Houtman - University of Iowa
Bryan G Allen - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: Journal of the American Heart Association, Vol.14(1), e039216
DOI: 10.1161/JAHA.124.039216
PMID: 39719411
PMCID: PMC12054428
NLM abbreviation: J Am Heart Assoc
ISSN: 2047-9980
eISSN: 2047-9980
Publisher: Wiley
Grant note: National Institutes of Health: UO1 AI184289, R21 CA270742-01
This work was supported by National Institutes of Health grants UO1 AI184289 and R21 CA270742-01.
Language: English
Electronic publication date: 12/24/2024
Date published: 01/07/2025
Academic Unit: Molecular Physiology and Biophysics; Microbiology and Immunology; Cardiovascular Medicine; Radiation Oncology; Holden Comprehensive Cancer Center; Internal Medicine
Record Identifier: 9984759992002771

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