Journal article
Immunopathogenesis of infection with the visceralizing Leishmania species
Microbial pathogenesis, Vol.38(4), pp.147-160
2005
DOI: 10.1016/j.micpath.2004.11.002
PMID: 15797810
Abstract
Human leishmaniasis is a spectral disease that includes asymptomatic self-resolving infection, localized skin lesions, and progressive visceral leishmaniasis. With some overlap, visceral and cutaneous leishmaniasis are usually caused by different species of Leishmania.
This review focuses on host responses to infection with the species that cause visceral leishmaniasis, as they contrast with species causing localized cutaneous leishmaniasis. Data from experimental models document significant differences between host responses to organisms causing these diverse syndromes. The visceralizing
Leishmania spp. cause localized organ-specific immune responses that are important determinants of disease outcome. Both the
Leishmania species causing cutaneous and those causing visceral leishmaniasis require a Type 1 immune response to undergo cure in mouse models. However, during progressive murine infection with the visceralizing
Leishmania sp., the Type 1 response is suppressed at least in part by TGF-β and IL-10 without type 2 cytokine production. This contrasts with the cutaneous species
L. major, in which a Type 2 response suppresses type 1 cytokines and leads to murine disease progression. Population and family studies are beginning to elucidate human genetic determinants predisposing to different outcomes of
Leishmania infection. These studies should eventually result in a better understanding of the immunopathogenesis and the spectrum of human leishmaniasis.
Details
- Title: Subtitle
- Immunopathogenesis of infection with the visceralizing Leishmania species
- Creators
- Mary E Wilson - Departments of Internal Medicine, Microbiology and Epidemiology, University of Iowa, The VA Medical Center, Iowa City, IA, USASelma M.B Jeronimo - Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal, RN, BrazilRichard D Pearson - Departments of Internal Medicine and Pathology, University of Virginia, Charlottesville, VA, USA
- Resource Type
- Journal article
- Publication Details
- Microbial pathogenesis, Vol.38(4), pp.147-160
- DOI
- 10.1016/j.micpath.2004.11.002
- PMID
- 15797810
- NLM abbreviation
- Microb Pathog
- ISSN
- 0882-4010
- eISSN
- 1096-1208
- Publisher
- Elsevier India Pvt Ltd
- Language
- English
- Date published
- 2005
- Academic Unit
- Microbiology and Immunology; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984001206602771
Metrics
23 Record Views