Journal article
Immunopathology in RSV Infection Is Mediated by a Discrete Oligoclonal Subset of Antigen-Specific CD4 + T Cells
Immunity (Cambridge, Mass.), Vol.15(4), pp.637-646
2001
DOI: 10.1016/S1074-7613(01)00209-6
PMID: 11672545
Abstract
Vaccination with the respiratory syncytial virus (RSV) attachment (G) protein results in immune-mediated lung injury after natural RSV infection with pathogenic features characteristic of an exaggerated Th2 response. Here we demonstrate that approximately half of the CD4
+ T cells infiltrating the lungs of G-primed mice utilize a single Vβ gene (Vβ14) with remarkably limited CDR3 diversity. Furthermore, elimination of these Vβ14-bearing CD4
+ T cells in vivo abolishes the type 2-like pulmonary injury. These results suggest that a novel subset of CD4
+ T cells may be crucial in the development of pathology during human RSV infection and that genetic or environmental factors prior to or at the time of G antigen exposure may affect the commitment of this discrete antigen-specific T cell subset to Th2 differentiation.
Details
- Title: Subtitle
- Immunopathology in RSV Infection Is Mediated by a Discrete Oligoclonal Subset of Antigen-Specific CD4 + T Cells
- Creators
- Steven M Varga - Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, VA 22908 USAXiaoting Wang - Program in Immunology and Virology, University of Massachusetts Medical Center, Worcester, MA 01655 USARaymond M Welsh - Department of Pathology, University of Massachusetts Medical Center, Worcester, MA 01655 USAThomas J Braciale - Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, VA 22908 USA
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.15(4), pp.637-646
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S1074-7613(01)00209-6
- PMID
- 11672545
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 2001
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; Pathology
- Record Identifier
- 9984083847602771
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