Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma

Adam C SEEGMILLER; Yin Xu; Robert W MCKENNA; Nitin J KARANDIKAR

doi:10.1309/5EL22BH45PHUPM8P

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Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma

Journal article

Open access

Peer reviewed

Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma

Adam C SEEGMILLER, Yin Xu, Robert W MCKENNA and Nitin J KARANDIKAR

American journal of clinical pathology, Vol.127(2), pp.176-181

2007

DOI: 10.1309/5EL22BH45PHUPM8P

PMID: 17210522

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Abstract

Some non-Hodgkin lymphomas show marked plasmacytic differentiation. In such cases, it may be difficult to differentiate these lymphomas from plasmacytoma or myeloma, especially with limited diagnostic material. However, there may be immunophenotypic differences in the plasma cells in these disorders that distinguish them. This study characterizes the immunophenotypes of neoplastic plasma cells in 41 cases of B-lineage non-Hodgkin lymphoma and compares them with those in plasma cell myeloma. We found that plasma cells in lymphoma were significantly more likely to express CD19, CD45, and surface immunoglobulin and less likely to express CD56 than those in myeloma. We further show that CD19 and CD56 expression can be used reliably to distinguish these entities. Myeloma-associated osseous lesions and solitary plasmacytoma of bone showed myeloma-like immunophenotypes. However, some extramedullary plasmacytomas showed lymphoma-like phenotypes, suggesting that, in reality, they may represent non-Hodgkin lymphomas with extensive plasmacytic differentiation.

Hematologic and hematopoietic diseases

Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis

Biological and medical sciences

Investigative techniques, diagnostic techniques (general aspects)

Medical sciences

Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques

Details

Title: Subtitle: Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma
Creators: Adam C SEEGMILLER - Department of Pathology, University of Texas Southwestern Medical Center at Dallas, United States
Yin Xu - Department of Pathology, University of Texas Southwestern Medical Center at Dallas, United States
Robert W MCKENNA - Department of Pathology, University of Texas Southwestern Medical Center at Dallas, United States
Nitin J KARANDIKAR - Department of Pathology, University of Texas Southwestern Medical Center at Dallas, United States
Resource Type: Journal article
Publication Details: American journal of clinical pathology, Vol.127(2), pp.176-181
DOI: 10.1309/5EL22BH45PHUPM8P
PMID: 17210522
NLM abbreviation: Am J Clin Pathol
ISSN: 0002-9173
eISSN: 1943-7722
Publisher: American Society of Clinical Pathologists; Chicago, IL
Language: English
Date published: 2007
Academic Unit: Pathology
Record Identifier: 9984047793402771

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