Journal article
Immunosuppression Considerations for Older Kidney Transplant Recipients
Current transplantation reports, Vol.8(2), pp.100-110
06/01/2021
DOI: 10.1007/s40472-021-00321-6
PMCID: PMC8244945
PMID: 34211822
Abstract
Purpose of Review While kidney transplantation improves the long-term survival of the majority of patients with end-stage kidney disease (ESKD), age-related immune dysfunction and associated comorbidities make older transplant recipients more susceptible to complications related to immunosuppression. In this review, we discuss appropriate management of immunosuppressive agents in older adults to minimize adverse events, avoid acute rejection, and maximize patient and graft survival. Recent Findings Physiological changes associated with senescence can impact drug metabolism and increase the risk of post-transplant infection and malignancy. Clinical trials assessing the safety and efficacy of immunosuppressive agents in older adults are lacking. Recent findings from U.S. transplant registry-based studies suggest that risk-adjusted death-censored graft failure is higher among older patients who received antimetabolite avoidance, mammalian target of rapamycin inhibitor (mTORi)-based, and cyclosporine-based regimens. Observational data suggest that risk-adjusted mortality may be increased in older patients who receive mTORi-based and cyclosporine-based regimens but lower in those managed with T cell induction and maintenance steroid avoidance/withdrawal. Tailored immunosuppression management to improve patient and graft survival in older transplant recipients is an important goal of personalized medicine. Lower intensity immunosuppression, such as steroid-sparing regimens, appears beneficial whereas mTORi- and cyclosporine-based maintenance are associated with greater potential for adverse effects. Prospective clinical trials to assess the safety and efficacy of immunosuppression agents in older recipients are urgently needed.
Details
- Title: Subtitle
- Immunosuppression Considerations for Older Kidney Transplant Recipients
- Creators
- Wisit Cheungpasitporn - Mayo ClinicKrista L. Lentine - St Louis Univ, Transplant Ctr, 1402 S Grand Blvd, St Louis, MO 63104 USAJane C. Tan - Stanford UniversityMatthew Kaufmann - Stanford UniversityYasar Caliskan - Saint Louis UniversitySuphamai Bunnapradist - University of California, Los AngelesNgan N. Lam - University of CalgaryMark Schnitzler - Saint Louis UniversityDavid A. Axelrod - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Current transplantation reports, Vol.8(2), pp.100-110
- DOI
- 10.1007/s40472-021-00321-6
- PMID
- 34211822
- PMCID
- PMC8244945
- NLM abbreviation
- Curr Transplant Rep
- ISSN
- 2196-3029
- eISSN
- 2196-3029
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- R01DK120518 / National Institute of Diabetes and Digestive and Kidney Disease (NIDDK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Mid-America Transplant/Jane A. Beckman Endowed Chair in Transplantation T32HS026128 / Agency for Healthcare Research and Quality; United States Department of Health & Human Services; Agency for Healthcare Research & Quality
- Language
- English
- Date published
- 06/01/2021
- Academic Unit
- Surgery
- Record Identifier
- 9984322794902771
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