Journal article
Immunosuppression and Resultant Viral Persistence by Specific Viral Targeting of Dendritic Cells
The Journal of experimental medicine, Vol.192(9), pp.1249-1260
11/06/2000
DOI: 10.1084/jem.192.9.1249
PMCID: PMC2193355
PMID: 11067874
Abstract
Among cells of the immune system, CD11c+ and DEC-205+ splenic dendritic cells primarily express the cellular receptor (α-dystroglycan [α-DG]) for lymphocytic choriomeningitis virus (LCMV). By selection, strains and variants of LCMV that bind α-DG with high affinity are associated with virus replication in the white pulp, show preferential replication in a majority of CD11c+ and DEC-205+ cells, cause immunosuppression, and establish a persistent infection. In contrast, viral strains and variants that bind with low affinity to α-DG are associated with viral replication in the red pulp, display minimal replication in CD11c+ and DEC-205+ cells, and generate a robust anti-LCMV cytotoxic T lymphocyte response that clears the virus infection. Differences in binding affinities can be mapped to a single amino acid change in the viral glycoprotein 1 ligand that binds to α-DG. These findings indicate that receptor–virus interaction on dendritic cells in vivo can be an essential step in the initiation of virus-induced immunosuppression and viral persistence.
Details
- Title: Subtitle
- Immunosuppression and Resultant Viral Persistence by Specific Viral Targeting of Dendritic Cells
- Creators
- Noemí Sevilla - Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037Stefan Kunz - Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037Andreas Holz - Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037Hanna Lewicki - Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037Dirk Homann - Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037Hiroki Yamada - Department of Physiology and Biophysics, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242Kevin P Campbell - Department of Physiology and Biophysics, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242Juan C de la Torre - Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037Michael B.A Oldstone - Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037
- Resource Type
- Journal article
- Publication Details
- The Journal of experimental medicine, Vol.192(9), pp.1249-1260
- DOI
- 10.1084/jem.192.9.1249
- PMID
- 11067874
- PMCID
- PMC2193355
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- Language
- English
- Date published
- 11/06/2000
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984068280802771
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