Journal article
Immunotherapeutics to Treat HIV in the Central Nervous System
Current HIV/AIDS reports, Vol.17(5), pp.499-506
10/01/2020
DOI: 10.1007/s11904-020-00519-w
PMCID: PMC7492473
PMID: 32671567
Abstract
Purpose of Review The application of immunotherapies to HIV presents a new horizon of treatment options, but little is known about what impact they may have on the central nervous system (CNS). Here we review the most promising immunotherapeutic strategies that can be used to target HIV in the CNS and focus on identifying their potential benefits while exploring the challenges that remain in their application. Recent Findings We have identified five immunotherapeutic strategies that hold potential in managing CNS disease among HIV-infected patients. These include broadly neutralizing antibodies, multi-affinity antibodies, CAR-T cell therapy, checkpoint inhibitors, and therapeutic vaccines. Each class of immunotherapy presents unique mechanisms by which CNS viremia and latency may be addressed but are faced with several challenges. CAR-T cell therapy and multi-affinity antibodies seem to hold promise, but combination therapy is likely to be most effective. However, more human trials are needed before the clinical benefits of these therapies are realized.
Details
- Title: Subtitle
- Immunotherapeutics to Treat HIV in the Central Nervous System
- Creators
- Andrew Kapoor - Beth Israel Deaconess Medical CenterC. Sabrina Tan - Beth Israel Deaconess Medical Center
- Resource Type
- Journal article
- Publication Details
- Current HIV/AIDS reports, Vol.17(5), pp.499-506
- DOI
- 10.1007/s11904-020-00519-w
- PMID
- 32671567
- PMCID
- PMC7492473
- NLM abbreviation
- Curr HIV/AIDS Rep
- ISSN
- 1548-3568
- eISSN
- 1548-3576
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- R21 MH112360; R33 MH112360 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Language
- English
- Date published
- 10/01/2020
- Academic Unit
- Iowa Neuroscience Institute; Internal Medicine
- Record Identifier
- 9984366367302771
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