Impact of COVID-19 pandemic on epilepsy care in Japan: A national-level multicenter retrospective cohort study

Naoto Kuroda; Takafumi Kubota; Toru Horinouchi; Naoki Ikegaya; Yu Kitazawa; Satoshi Kodama; Izumi Kuramochi; Teppei Matsubara; Naoto Nagino; Shuichiro Neshige; Temma Soga; Yutaro Takayama; Daichi Sone; Kousuke Kanemoto; Akio Ikeda; Kiyohito Terada; Hiroko Goji; Shinji Ohara; Koichi Hagiwara; Takashi Kamada; Koji Iida; Nobutsune Ishikawa; Hideaki Shiraishi; Osato Iwata; Hidenori Sugano; Yasushi Iimura; Takuichiro Higashi; Hiroshi Hosoyama; Ryosuke Hanaya; Akihiro Shimotake; Takayuki Kikuchi; Takeshi Yoshida; Hiroshi Shigeto; Jun Yokoyama; Takahiko Mukaino; Masaaki Kato; Masanori Sekimoto; Masahiro Mizobuchi; Yoko Aburakawa; Masaki Iwasaki; Eiji Nakagawa; Tomohiro Iwata; Kentaro Tokumoto; Takuji Nishida; Yukitoshi Takahashi; Kenjiro Kikuchi; Ryuki Matsuura; Shin ichiro Hamano; Ayataka Fujimoto; Hideo Enoki; Kyoichi Tomoto; Masako Watanabe; Youji Takubo; Toshihiko Fukuchi; Hidetoshi Nakamoto; Yuichi Kubota; Naoto Kunii; Yuichiro Shirota; Eiichi Ishikawa; Nobukazu Nakasato; Taketoshi Maehara; Motoki Inaji; Shunsuke Takagi; Takashi Enokizono; Yosuke Masuda; Takahiro Hayashi; IMPACT‐J EPILEPSY (In‐depth Multicenter analysis during Pandemic of Covid‐19 Throughout Japan for EPILEPSY practice) study group

doi:10.1002/epi4.12616

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Impact of COVID-19 pandemic on epilepsy care in Japan: A national-level multicenter retrospective cohort study

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Impact of COVID-19 pandemic on epilepsy care in Japan: A national-level multicenter retrospective cohort study

Naoto Kuroda, Takafumi Kubota, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Izumi Kuramochi, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, …

Epilepsia open, Vol.7(3), pp.431-441

09/2022

DOI: 10.1002/epi4.12616

PMID: 35633311

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Abstract

Objective The impact of the coronavirus disease 2019 (COVID-19) pandemic on epilepsy care across Japan was investigated by conducting a multicenter retrospective cohort study. Methods This study included monthly data on the frequency of (1) visits by outpatients with epilepsy, (2) outpatient electroencephalography (EEG) studies, (3) telemedicine for epilepsy, (4) admissions for epilepsy, (5) EEG monitoring, and (6) epilepsy surgery in epilepsy centers and clinics across Japan between January 2019 and December 2020. We defined the primary outcome as epilepsy center-specific monthly data divided by the 12-month average in 2019 for each facility. We determined whether the COVID-19 pandemic-related factors (such as year [2019 or 2020], COVID-19 cases in each prefecture in the previous month, and a state of emergency) were independently associated with these outcomes. Results In 2020, the frequency of outpatient EEG studies (−10.7%, P < .001) and cases with telemedicine (+2608%, P = .031) were affected. The number of COVID-19 cases was an independent associated factor for epilepsy admission (−3.75 × 10−3% per case, P < .001) and EEG monitoring (−3.81 × 10−3% per case, P = .004). Furthermore, a state of emergency was an independent factor associated with outpatient with epilepsy (−11.9%, P < .001), outpatient EEG (−32.3%, P < .001), telemedicine for epilepsy (+12,915%, P < .001), epilepsy admissions (−35.3%; P < .001), EEG monitoring (−24.7%: P < .001), and epilepsy surgery (−50.3%, P < .001). Significance We demonstrated the significant impact that the COVID-19 pandemic had on epilepsy care. These results support those of previous studies and clarify the effect size of each pandemic-related factor on epilepsy care.

Neurology

Neurosurgery

epilepsy center

hospitalization

SARS-CoV-2

Details

Title: Subtitle: Impact of COVID-19 pandemic on epilepsy care in Japan: A national-level multicenter retrospective cohort study
Creators: Naoto Kuroda - Wayne State University
Takafumi Kubota - University Hospitals of Cleveland
Toru Horinouchi - Hokkaido University
Naoki Ikegaya - YKK (Japan)
Yu Kitazawa - Yokohama City University
Satoshi Kodama - The University of Tokyo
Izumi Kuramochi - Social Insurance Saitama Chuo Hospital
Teppei Matsubara - Massachusetts General Hospital
Naoto Nagino - YKK (Japan)
Shuichiro Neshige - Hiroshima University
Temma Soga - Tohoku University
Yutaro Takayama - National Center of Neurology and Psychiatry
Daichi Sone - University College London
Kousuke Kanemoto
Akio Ikeda
Kiyohito Terada
Hiroko Goji
Shinji Ohara
Koichi Hagiwara
Takashi Kamada
Koji Iida
Nobutsune Ishikawa
Hideaki Shiraishi
Osato Iwata
Hidenori Sugano
Yasushi Iimura
Takuichiro Higashi
Hiroshi Hosoyama
Ryosuke Hanaya
Akihiro Shimotake
Takayuki Kikuchi
Takeshi Yoshida
Hiroshi Shigeto
Jun Yokoyama
Takahiko Mukaino
Masaaki Kato
Masanori Sekimoto
Masahiro Mizobuchi
Yoko Aburakawa
Masaki Iwasaki
Eiji Nakagawa
Tomohiro Iwata
Kentaro Tokumoto
Takuji Nishida
Yukitoshi Takahashi
Kenjiro Kikuchi
Ryuki Matsuura
Shin ichiro Hamano
Ayataka Fujimoto
Hideo Enoki
Kyoichi Tomoto
Masako Watanabe
Youji Takubo
Toshihiko Fukuchi
Hidetoshi Nakamoto
Yuichi Kubota
Naoto Kunii
Yuichiro Shirota
Eiichi Ishikawa
Nobukazu Nakasato
Taketoshi Maehara
Motoki Inaji
Shunsuke Takagi
Takashi Enokizono
Yosuke Masuda
Takahiro Hayashi
IMPACT‐J EPILEPSY (In‐depth Multicenter analysis during Pandemic of Covid‐19 Throughout Japan for EPILEPSY practice) study group
Resource Type: Journal article
Publication Details: Epilepsia open, Vol.7(3), pp.431-441
DOI: 10.1002/epi4.12616
PMID: 35633311
NLM abbreviation: Epilepsia Open
ISSN: 2470-9239
eISSN: 2470-9239
Publisher: Wiley
Number of pages: 11
Grant note: Detroit Medical Center Children's Hospital of Michigan (http://data.elsevier.com/vocabulary/SciValFunders/501100019830) 19K18435 / Japan Society for the Promotion of Science (501100001691) 20K09341; 19K18435 / Japan Society for the Promotion of Science (http://data.elsevier.com/vocabulary/SciValFunders/501100001691) Wayne State University (http://data.elsevier.com/vocabulary/SciValFunders/100006710)
Language: English
Date published: 09/2022
Academic Unit: Neurology
Record Identifier: 9985177944102771

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