Journal article
Impact of Child Sex Abuse on Adult Psychopathology: A Genetically and Epigenetically Informed Investigation
Journal of family psychology, Vol.27(1), pp.3-11
02/2013
DOI: 10.1037/a0031459
PMCID: PMC3813956
PMID: 23421829
Abstract
Genetic, environmental, and epigenetic influences and their transactions were examined in a sample of 155 women from the Iowa Adoptee sample (IAS) who had been removed from their biological parents shortly after birth, and assessed when participants were an average of 41.10 years old. We observed an interactive effect of child sex abuse (CSA) and biological parent psychopathology (i.e., genetic load) on substance abuse as well as a main effect of CSA on substance abuse in adulthood. We also observed main effects of CSA and genetic load on depression and on antisocial characteristics. As predicted, CSA, but not genetic load or later substance abuse, was associated with epigenetic change. In addition, the interaction between genetic load and CSA predicted epigenetic change, indicating a potential genetic basis for differential impact of CSA on epigenetic change. Finally, epigenetic change partially mediated the effect of CSA on antisocial characteristics. The results suggest the relevance of genetic and epigenetic processes for future theorizing regarding marital and family precursors of several forms of adult psychopathology. Implications for preventive intervention are discussed.
Details
- Title: Subtitle
- Impact of Child Sex Abuse on Adult Psychopathology: A Genetically and Epigenetically Informed Investigation
- Creators
- Steven R. H Beach - University of GeorgiaGene H Brody - University of GeorgiaMan Kit Lei - University of GeorgiaFrederick X Gibbons - University of ConnecticutMeg Gerrard - University of ConnecticutRonald L Simons - University of GeorgiaCarolyn E Cutrona - Iowa State UniversityRobert A Philibert - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of family psychology, Vol.27(1), pp.3-11
- DOI
- 10.1037/a0031459
- PMID
- 23421829
- PMCID
- PMC3813956
- NLM abbreviation
- J Fam Psychol
- ISSN
- 0893-3200
- eISSN
- 1939-1293
- Grant note
- P30 DA027827 || DA / National Institute on Drug Abuse : NIDA R01 DA015789 || DA / National Institute on Drug Abuse : NIDA
- Language
- English
- Date published
- 02/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003412202771
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