Impact of Donor Cause of Death on Transplant Outcomes: UNOS Registry Analysis

A. K SINGHAL; X SHENG; S. G DRAKOS; J STEHLIK

doi:10.1016/j.transproceed.2009.06.192

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Impact of Donor Cause of Death on Transplant Outcomes: UNOS Registry Analysis

Journal article

Peer reviewed

Impact of Donor Cause of Death on Transplant Outcomes: UNOS Registry Analysis

A. K SINGHAL, X SHENG, S. G DRAKOS and J STEHLIK

Transplantation proceedings, Vol.41(9), pp.3539-3544

2009

DOI: 10.1016/j.transproceed.2009.06.192

PMID: 19917340

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Abstract

Donor cause of death (DCOD) has been described to influence allograft survival. Whether this effect is independent of other donor characteristics and whether it is similar across different solid organ allografts is not known. The aim of our study was to determine the impact of DCOD on organ utilization and on transplantation outcomes—graft rejection, function, and survival. The registry data were provided by the United Network for Organ Sharing/Organ Procurement and Transplantation Network. Stroke, head trauma, and anoxia were the cause of brain death in 97% of the more than 86,000 donors whose data were recorded between 1989 and 2008. In univariate analysis, stroke DCOD was associated with worse graft survival across all organs. After adjustment in a multivariable analysis, modest differences persisted in survival of heart, kidney, and liver allografts. DCOD also appeared to affect the incidence of allograft rejection. Anoxia DCOD was associated with significantly less rejection relative to donor death caused by head trauma and stroke. In summary, this multi-institutional study confirms that DCOD is a modest predictor of survival and rejection of solid organ allografts of different types.

Fundamental and applied biological sciences. Psychology

Fundamental immunology

Biological and medical sciences

Tissue, organ and graft immunology

Medical sciences

Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases

Details

Title: Subtitle: Impact of Donor Cause of Death on Transplant Outcomes: UNOS Registry Analysis
Creators: A. K SINGHAL - Department of Surgery, University of Utah, Salt Lake City, Utah, United States
X SHENG - Department of Surgery, University of Utah, Salt Lake City, Utah, United States
S. G DRAKOS - Department of Surgery, University of Utah, Salt Lake City, Utah, United States
J STEHLIK - Department of Surgery, University of Utah, Salt Lake City, Utah, United States
Resource Type: Journal article
Publication Details: Transplantation proceedings, Vol.41(9), pp.3539-3544
Publisher: Elsevier; Amsterdam
DOI: 10.1016/j.transproceed.2009.06.192
PMID: 19917340
ISSN: 0041-1345
eISSN: 1873-2623
Language: English
Date published: 2009
Academic Unit: Surgery; Cardiothoracic Surgery
Record Identifier: 9984051567902771

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