Impact of EcSOD Perturbations in Cancer Progression

Brianne R. O'Leary; Rory S. Carroll; Garett J. Steers; Jennifer Hrabe; Frederick E. Domann; Joseph J. Cullen

doi:10.3390/antiox10081219

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Impact of EcSOD Perturbations in Cancer Progression

Journal article

Open access

Peer reviewed

Impact of EcSOD Perturbations in Cancer Progression

Brianne R. O'Leary, Rory S. Carroll, Garett J. Steers, Jennifer Hrabe, Frederick E. Domann and Joseph J. Cullen

Antioxidants, Vol.10(8), p.1219

08/01/2021

DOI: 10.3390/antiox10081219

PMCID: PMC8388922

PMID: 34439467

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Abstract

Reactive oxygen species (ROS) are a normal byproduct of cellular metabolism and are required components in cell signaling and immune responses. However, an imbalance of ROS can lead to oxidative stress in various pathological states. Increases in oxidative stress are one of the hallmarks in cancer cells, which display an altered metabolism when compared to corresponding normal cells. Extracellular superoxide dismutase (EcSOD) is an antioxidant enzyme that catalyzes the dismutation of superoxide anion (O-2(-)) in the extracellular environment. By doing so, this enzyme provides the cell with a defense against oxidative damage by contributing to redox balance. Interestingly, EcSOD expression has been found to be decreased in a variety of cancers, and this loss of expression may contribute to the development and progression of malignancies. In addition, recent compounds can increase EcSOD activity and expression, which has the potential for altering this redox signaling and cellular proliferation. This review will explore the role that EcSOD expression plays in cancer in order to better understand its potential as a tool for the detection, predicted outcomes and potential treatment of malignancies.

Biochemistry & Molecular Biology

Chemistry, Medicinal

Food Science & Technology

Life Sciences & Biomedicine

Pharmacology & Pharmacy

Science & Technology

Details

Title: Subtitle: Impact of EcSOD Perturbations in Cancer Progression
Creators: Brianne R. O'Leary - University of Iowa
Rory S. Carroll - University of Iowa
Garett J. Steers - University of Iowa
Jennifer Hrabe - University of Iowa
Frederick E. Domann - University of Iowa
Joseph J. Cullen - University of Iowa
Resource Type: Journal article
Publication Details: Antioxidants, Vol.10(8), p.1219
DOI: 10.3390/antiox10081219
PMID: 34439467
PMCID: PMC8388922
NLM abbreviation: Antioxidants (Basel)
ISSN: 2076-3921
eISSN: 2076-3921
Publisher: Mdpi
Number of pages: 16
Grant note: P01CA217797; T32 CA148062 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
Language: English
Date published: 08/01/2021
Academic Unit: Surgery; Radiation Oncology
Record Identifier: 9984312973902771

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