Journal article
Impact of Elevated Serum Triglycerides on Children with Acute Recurrent or Chronic Pancreatitis from INSPPIRE-2
The Journal of pediatrics, Vol.276, 114298
01/2025
DOI: 10.1016/j.jpeds.2024.114298
PMCID: PMC11645242
PMID: 39277078
Abstract
To determine if mild-moderate hypertriglyceridemia is associated with increased development of chronic pancreatitis or pancreatitis-associated complications in children with acute recurrent or chronic pancreatitis.
Longitudinal data from the INSPPIRE-2 (INternational Study group of Pediatric Pancreatitis: In search for a cuRE-2) cohort of children with acute recurrent or chronic pancreatitis (n=559) were analyzed. Subjects were divided into normal triglycerides (<150 mg/dL; 1.7 mmol/L), any hypertriglyceridemia (≥150 mg/dL; ≥1.7 mmol/L), mild-moderate hypertriglyceridemia (150-499 mg/dL; 1.7-5.6 mmol/L), moderate hypertriglyceridemia (500-999 mg/dL; 5.6-11.3 mmol/L), and severe hypertriglyceridemia groups (≥1,000 mg/dL; ≥11.3 mmol/L), based on highest serum triglyceride value. Laboratory, imaging, pancreatitis and hospital events, complications, and quality of life data were analyzed.
In children with acute recurrent or chronic pancreatitis and hypertriglyceridemia, there was no increase in the number of pancreatitis attacks per person-years, nor an increase in chronic pancreatitis prevalence. However, hypertriglyceridemia severity was associated with increased pancreatic inflammation, pancreatic cysts, pain, hospital days, number of hospitalizations, intensive care, and missed school days.
Mild-moderate hypertriglyceridemia in children with acute recurrent or chronic pancreatitis was not associated with increased pancreatitis frequency, nor increased development of chronic pancreatitis, but was associated with increased pancreatitis complications and disease burden. As a treatable condition, treatment of mild-moderate hypertriglyceridemia may be considered to reduce pancreatitis-associated complications and medical burden in children with acute recurrent or chronic pancreatitis.
Details
- Title: Subtitle
- Impact of Elevated Serum Triglycerides on Children with Acute Recurrent or Chronic Pancreatitis from INSPPIRE-2
- Creators
- Zachary M. Sellers - Stanford UniversityMatthew J. Giefer - Ochsner Medical CenterFuchenchu Wang - The University of Texas MD Anderson Cancer CenterGretchen A. Cress - University of IowaMaisam A. Abu-El-Haija - University of CincinnatiAnkur Chugh - Medical College of WisconsinReuven Z. Cohen - Emory UniversityElissa M. Downs - University of Minnesota Children's HospitalDouglas S. Fishman - Baylor College of MedicineA. Jay Freeman - The Ohio State UniversityCheryl E. Gariepy - Nationwide Children's HospitalTanja Y. Gonska - University of TorontoAmit S. Grover - Harvard UniversityDoug Lindblad - Children's Hospital of PittsburghQuin Y. Liu - Cedars-Sinai Medical CenterAsim Maqbool - Children's Hospital of PhiladelphiaJacob A. Mark - Children's Hospital ColoradoBrian A. McFerron - Riley Hospital for ChildrenMegha S. Mehta - The University of Texas Southwestern Medical CenterVeronique D. Morinville - Montreal Children's HospitalKenneth Ng - Johns Hopkins Children's CenterRobert A. Noel - Baylor College of MedicineChee Y. Ooi - UNSW SydneyEmily R. Perito - University of California, San FranciscoMadhura Y. Phadke - Children's Hospital of PittsburghWenly Ruan - Texas Children's HospitalSarah Jane Schwarzenberg - University of Minnesota Children's HospitalDavid M. Troendle - The University of Texas Southwestern Medical CenterMichael Wilschanski - Hebrew University of JerusalemYuhua Zheng - Children's Hospital of Los AngelesYing Yuan - The University of Texas MD Anderson Cancer CenterMark E. Lowe - Washington University in St. LouisAliye Uc - University of IowaConsortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.276, 114298
- DOI
- 10.1016/j.jpeds.2024.114298
- PMID
- 39277078
- PMCID
- PMC11645242
- NLM abbreviation
- J Pediatr
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Publisher
- Elsevier Inc
- Grant note
- National Institute of Diabetes and Digestive and Kidney Diseases and Na-tional Cancer Institute of the National Institutes of Health: 2U01 DK108334, 2U01DK108328, R01DK118752
This study received funding from National Institute of Diabetes and Digestive and Kidney Diseases and Na-tional Cancer Institute of the National Institutes of Health under award numbers 2U01 DK108334, 2U01DK108328, R01DK118752 (A.U.) . The content is solely the respon-sibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- Language
- English
- Electronic publication date
- 09/12/2024
- Date published
- 01/2025
- Academic Unit
- Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984705606302771
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