Impact of GB virus type C infection on mother-to-child HIV transmission in the Women and Infants Transmission Study Cohort

E Handelsman; I Cheng; B Thompson; R Hershow; L M Mofenson; F B Hollinger; K T Chen; S K Burchett; D Klinzman; J T Stapleton; Women and Infants Transmission Study Group (WITS)

doi:10.1111/j.1468-1293.2007.00510.x

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Impact of GB virus type C infection on mother-to-child HIV transmission in the Women and Infants Transmission Study Cohort

Journal article

Open access

Peer reviewed

Impact of GB virus type C infection on mother-to-child HIV transmission in the Women and Infants Transmission Study Cohort

E Handelsman, I Cheng, B Thompson, R Hershow, L M Mofenson, F B Hollinger, K T Chen, S K Burchett, D Klinzman, J T Stapleton, …

HIV medicine, Vol.8(8), pp.561-567

11/2007

DOI: 10.1111/j.1468-1293.2007.00510.x

PMID: 17944690

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Abstract

GB virus type C (GBV-C) viraemia is associated with a beneficial outcome in HIV-infected individuals in several though not all studies. GBV-C viraemia was examined in a matched case-control study of 133 HIV-infected pregnant women who transmitted HIV to their infants ('cases') and 266 non-transmitting controls. HIV-infected children and controls were pair-matched for high-risk delivery, race and year of delivery. GBV-C status was determined in maternal plasma samples obtained at or within 3 months of delivery. Pregnant women with GBV-C viraemia (11% of those studied) had lower HIV RNA levels (P=0.01) and higher CD4 percentages (P=0.0006) [corrected] than women without GBV-C. A trend towards decreased mother-to-child transmission in the multivariate analysis was observed among GBV-C viraemic women delivering after highly active antiretroviral therapy (HAART) became available [odds ratio (OR) 0.30, 95% confidence interval (CI) 0.08-1.05; P=0.06], but not in women delivering prior to the widespread use of HAART. GBV-C viraemia was associated with a beneficial effect on CD4 percentage and HIV RNA level in these pregnant women, and was also associated with a trend towards reduced risk of mother-to-child HIV transmission among women after HAART became available. Further studies with larger or multiple cohorts are necessary to assess possible benefits in this population.

Pregnancy

Pregnancy Complications, Infectious - virology

HIV Infections - epidemiology

Humans

Flaviviridae Infections - epidemiology

GB virus C

CD4 Lymphocyte Count

Flaviviridae Infections - transmission

Case-Control Studies

Antiretroviral Therapy, Highly Active

Flaviviridae Infections - drug therapy

HIV Infections - complications

Female

HIV Infections - transmission

Infectious Disease Transmission, Vertical - statistics & numerical data

Infant, Newborn

Cohort Studies

Details

Title: Subtitle: Impact of GB virus type C infection on mother-to-child HIV transmission in the Women and Infants Transmission Study Cohort
Creators: E Handelsman - SUNY Downstate, Brooklyn, NY, USA
I Cheng - Clinical Trials and Surveys Corporation
B Thompson - Clinical Trials and Surveys Corporation
R Hershow - University of Illinois at Chicago
L M Mofenson
F B Hollinger - Baylor College of Medicine
K T Chen - Columbia University
S K Burchett - Harvard Medical School
D Klinzman - University of Iowa
J T Stapleton
Women and Infants Transmission Study Group (WITS)
Resource Type: Journal article
Publication Details: HIV medicine, Vol.8(8), pp.561-567
DOI: 10.1111/j.1468-1293.2007.00510.x
PMID: 17944690
ISSN: 1464-2662
eISSN: 1468-1293
Grant note: U01 HD 041983 / NICHD NIH HHS N01 AI 085339 / NIAID NIH HHS U01 AI 034858 / NIAID NIH HHS AI58740 / NIAID NIH HHS 1 U01 AI 050274-01 / NIAID NIH HHS RR000188 / NCRR NIH HHS U01 HD 036117 / NICHD NIH HHS U01 AI 034841 / NIAID NIH HHS U01 DA 015053 / NIDA NIH HHS 9U01 DA 015054 / NIDA NIH HHS RR000645 / NCRR NIH HHS
Language: English
Date published: 11/2007
Academic Unit: Microbiology and Immunology; Infectious Diseases; Internal Medicine
Record Identifier: 9984094355502771

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