Journal article
Impact of Ga-68-Prostate-Specific Membrane Antigen PET/CT on Prostate Cancer Management
The Journal of nuclear medicine (1978), Vol.59(1), pp.89-92
01/01/2018
DOI: 10.2967/jnumed.117.192625
PMID: 28747520
Abstract
The objective of this study was to assess the impact of Ga-68-prostate-specific membrane antigen (Ga-68-PSMA) PET/CT on the management of prostate cancer in patients with biochemical recurrence (BCR). Methods: Documented management plans before and after Ga-68-PSMA PET/CT in 100 patients with BCR were retrospectively reviewed, and changes in plans were recorded. Results: Management changed after Ga-68-PSMA PET/CT in 39 patients (39%). The management changes occurred in 23 (33.8%) of 68 patients with radical prostatectomy and 16 (50%) of 32 patients previously treated with radical radiotherapy. Positive scan results (P < 0.001) and higher prostate-specific antigen (PSA) levels (P = 0.024) were associated with management changes. No significant association with management change was found for Gleason grade, stage, presence of metastatic disease, PSA velocity, or PSA doubling time. Conclusion: Ga-68-PSMA PET/CT altered management in 39% of patients with BCR, and changes occurred more often in patients with radical radiotherapy treatment, positive Ga-68-PSMA scan results, and higher PSA levels.
Details
- Title: Subtitle
- Impact of Ga-68-Prostate-Specific Membrane Antigen PET/CT on Prostate Cancer Management
- Creators
- Asim Afaq - University College HospitalSuliman Alahmed - King Khalid University HospitalShih-hsin Chen - Chang Gung Memorial HospitalThabo Lengana - Steve Biko HospitalAthar Haroon - Barts Health NHS TrustHeather Payne - University College HospitalHashim Ahmed - University College HospitalShonit Punwani - University College LondonMike Sathekge - Steve Biko HospitalJamshed Bomanji - University College London
- Resource Type
- Journal article
- Publication Details
- The Journal of nuclear medicine (1978), Vol.59(1), pp.89-92
- DOI
- 10.2967/jnumed.117.192625
- PMID
- 28747520
- NLM abbreviation
- J Nucl Med
- ISSN
- 0161-5505
- eISSN
- 1535-5667
- Publisher
- Soc Nuclear Medicine Inc
- Number of pages
- 4
- Grant note
- UCL Experimental Cancer Medicine Centre G0701302 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission UCLH/UCL Comprehensive Biomedical Research Centre CL-2007-18-015 / National Institute for Health Research; National Institute for Health Research (NIHR) London North West Healthcare Charitable Fund G1002509 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) PG13-025 / Prostate Cancer UK 16463 / Cancer Research UK UCLH NIHR BRC
- Language
- English
- Date published
- 01/01/2018
- Academic Unit
- Radiology
- Record Identifier
- 9984318816902771
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