Journal article
Impact of Immunosuppressive Therapy, Vaccination, and Monoclonal Antibody Use With Outcomes in Liver and Kidney Transplant Recipients With COVID-19: A Retrospective Study
JGH open, Vol.8(12), e70072
12/04/2024
DOI: 10.1002/jgh3.70072
PMCID: PMC11617588
PMID: 39639985
Appears in UI Libraries Support Open Access
Abstract
Patients who have undergone solid organ transplantation are at an elevated risk of severe coronavirus disease (COVID-19) because of post-transplantation immunosuppressive therapy. However, optimization of vaccination, modification of immunosuppression, and implementation of monoclonal antibody (mAb) therapy in transplant recipients with COVID-19 is uncertain.
A retrospective cross-sectional study was conducted on patients who underwent liver or kidney transplants and were diagnosed with COVID-19. The association of several vaccine doses, mycophenolate therapy, and mAB therapy with mortality outcomes after COVID-19 diagnosis (3 and 6 months), hospitalization, and length of hospital stay were assessed.
This study included 255 patients with a median age of 59 (23-89) were included. Many COVID-19 vaccine doses were not associated with any outcome; however, patients with a liver transplanted with mycophenolate had higher 3-month (19% vs. 0%;
= 0.02) and 6-month (21% vs. 0%;
= 0.01) mortality rates than those who did not. In addition, transplant recipients who received mAb therapy for COVID-19 were less likely to be hospitalized (37% vs. 68%;
< 0.001).
For organ transplant recipients with COVID-19, vaccination alone may not be an optimal strategy for preventing serious outcomes. Rather, the types of organ transplant, immunosuppressive therapy (particularly mycophenolate), and COVID-19 treatment strategy should be synergistically considered to promote an optimal therapeutic dynamic for a vulnerable population.
Details
- Title: Subtitle
- Impact of Immunosuppressive Therapy, Vaccination, and Monoclonal Antibody Use With Outcomes in Liver and Kidney Transplant Recipients With COVID-19: A Retrospective Study
- Creators
- Ashley Francis - Wayne State UniversityAmmad Javaid Chaudhary - Henry Ford HospitalAbdullah Sohail - University of IowaZahid I Tarar - University of MissouriAli Jaan - Rochester General HospitalJoseph P Cavataio - Wayne State UniversitySara Farooqui - Wayne State UniversityAdarsh Varma - Henry Ford HospitalSyed-Mohammed Jafri - Henry Ford Hospital
- Resource Type
- Journal article
- Publication Details
- JGH open, Vol.8(12), e70072
- DOI
- 10.1002/jgh3.70072
- PMID
- 39639985
- PMCID
- PMC11617588
- NLM abbreviation
- JGH Open
- ISSN
- 2397-9070
- eISSN
- 2397-9070
- Publisher
- Wiley; HOBOKEN
- Language
- English
- Date published
- 12/04/2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984757276702771
Metrics
9 Record Views