Journal article
Impact of Inflammatory Cytokines on Effector and Memory CD8+ T Cells
Frontiers in immunology, Vol.5, pp.295-295
2014
DOI: 10.3389/fimmu.2014.00295
PMCID: PMC4062963
PMID: 24995011
Abstract
Inflammatory cytokines have long been recognized to produce potent APCs to elicit robust T cell responses for protective immunity. The impact of inflammatory cytokine signaling directly on T cells, however, has only recently been appreciated. Although much remains to be learned, the CD8 T cell field has made considerable strides in understanding the effects of inflammatory cytokines throughout the CD8 T cell response. Key findings first identified IL-12 and type I interferons as “signal 3” cytokines, emphasizing their importance in generating optimal CD8 T cell responses. Separate investigations revealed another inflammatory cytokine, IL-15, to play a critical role in memory CD8 T cell maintenance. These early studies highlighted potential regulators of CD8 T cells, but were unable to provide mechanistic insight into how these inflammatory cytokines enhanced CD8 T cell-mediated immunity. Here, we describe the mechanistic advances that have been made in our lab regarding the role of “signal 3” cytokines and IL-15 in optimizing effector and memory CD8 T cell number and function. Furthermore, we assess initial progress on the role of cytokines, such as TGF-β, in generation of recently described resident memory CD8 T cell populations.
Details
- Title: Subtitle
- Impact of Inflammatory Cytokines on Effector and Memory CD8+ T Cells
- Creators
- Marie T Kim - Interdisciplinary Program in Immunology, University of IowaJohn T Harty - Interdisciplinary Program in Immunology, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Frontiers in immunology, Vol.5, pp.295-295
- DOI
- 10.3389/fimmu.2014.00295
- PMID
- 24995011
- PMCID
- PMC4062963
- NLM abbreviation
- Front Immunol
- ISSN
- 1664-3224
- eISSN
- 1664-3224
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 2014
- Academic Unit
- Pathology
- Record Identifier
- 9984047634602771
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