Journal article
Impact of KRAS status on tumor response and survival after neoadjuvant treatment of locally advanced rectal cancer
Journal of surgical oncology, Vol.123(1), pp.278-285
01/2021
DOI: 10.1002/jso.26244
PMID: 33022750
Abstract
Mutation of the KRAS oncogene (mKRAS) in colorectal cancer has been associated with aggressive tumor biology, resistance to epidermal growth factor inhibitors, and decreased overall survival (OS). The aim of the current study was to analyze the association of mKRAS with pathologic complete response (pCR) and neoadjuvant rectal (NAR) score, and its impact on the survival of patients with locally advanced rectal cancer who were managed with multimodality therapy.
The National Cancer Database was queried for stage II-III rectal cancer patients with a known KRAS status who underwent neoadjuvant chemoradiation therapy (nCRT) and proctectomy between 2004 and 2015.
In total, 1886 patients were identified; 12% had pCR and 36% had mKRAS. Patients with mKRAS were more likely to have advanced pathologic T stage, tumor deposits, perineural invasion, and elevated carcinoembryonic antigen levels (all p ≤ .05). After adjustment for available confounders, mKRAS status was not associated with pCR or NAR score. In multivariable analysis, patients with pCR and lower NAR score had better OS, whereas mKRAS was independently associated with a worse prognosis.
In this cohort of locally advanced rectal cancer patients who underwent proctectomy after nCRT, mKRAS was not associated with lower pCR rates or NAR scores; however, these patients experienced worse survival.
Details
- Title: Subtitle
- Impact of KRAS status on tumor response and survival after neoadjuvant treatment of locally advanced rectal cancer
- Creators
- Peige Zhou - University of IowaPaolo Goffredo - University of Iowa Hospitals and ClinicsTimothy Ginader - University of IowaDakota Thompson - University of IowaJennifer Hrabe - University of Iowa Hospitals and ClinicsIrena Gribovskaja-Rupp - University of Iowa Hospitals and ClinicsMuneera Kapadia - University of North Carolina at Chapel HillImran Hassan - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Journal of surgical oncology, Vol.123(1), pp.278-285
- DOI
- 10.1002/jso.26244
- PMID
- 33022750
- ISSN
- 0022-4790
- eISSN
- 1096-9098
- Language
- English
- Date published
- 01/2021
- Academic Unit
- Surgery
- Record Identifier
- 9984322829302771
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