Journal article
Impact of Marijuana Smoking on COPD Progression in a Cohort of Middle-Aged and Older Persons
Chronic obstructive pulmonary diseases, Vol.10(3), pp.234-247
2023
DOI: 10.15326/jcopdf.2022.0378
PMCID: PMC10484485
PMID: 37199732
Abstract
Limited data are available regarding marijuana smoking's impact on development or progression of chronic obstructive pulmonary disease (COPD) in middle-aged or older adults with a variable history of tobacco cigarette smoking.
We divided ever-tobacco smoking participants in the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) into three groups based on self-reported marijuana use: current, former or never marijuana smokers (CMS, FMS or NMS, respectively). Longitudinal data were analyzed in participants with ≥2 visits over a period of ≥52 weeks.
We compared CMS, FMS and NMS, and those with varying amounts of lifetime marijuana use. Mixed effects linear regression models were used to analyze changes in spirometry, symptoms, health status and radiographic metrics; zero-inflated negative binomial models were used for exacerbation rates. All models were adjusted for age, sex, race, baseline tobacco smoking amount, and FEV
%predicted.
Most participants were followed for ≥4 years. Annual rates of change in FEV
, incident COPD, respiratory symptoms, health status, radiographic extent of emphysema or air trapping, and total or severe exacerbations were not different between CMS or FMS versus NMS or between those with any lifetime amount of marijuana use versus NMS.
Among SPIROMICS participants with or without COPD, neither former nor current marijuana smoking of any lifetime amount was associated with evidence of COPD progression or its development. Because of our study's limitations, these findings underscore the need for further studies to better understand longer term effects of marijuana smoking in COPD.
Details
- Title: Subtitle
- Impact of Marijuana Smoking on COPD Progression in a Cohort of Middle-Aged and Older Persons
- Creators
- Igor Barjaktarevic - Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United StatesChristopher B Cooper - University of California, Los AngelesTracie Shing - Collaborative Studies Coordinating Center, Department of Biostatistics, Gilling's School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United StatesRussell G Buhr - Center for the Study of Healthcare Provider BehaviorEric A Hoffman - Departments of Radiology, Medicine and Bioengineering, University of Iowa, Iowa City, Iowa, United StatesPrescott G WoodruffM Bradley Drummond - Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, United StatesRichard E Kanner - University of UtahMeiLan K Han - University of Michigan–Ann ArborNadia N Hansel - Johns Hopkins UniversityRussell P Bowler - National Jewish HealthGregory L Kinney - University of Colorado Anschutz Medical CampusSean Jacobson - University of Colorado Anschutz Medical CampusMadeline A Morris - University of VermontFernando J Martinez - Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, New York, United StatesJill Ohar - Wake Forest UniversityDavid Couper - Collaborative Studies Coordinating Center, Department of Biostatistics, Gilling's School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United StatesDonald P Tashkin - Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States
- Resource Type
- Journal article
- Publication Details
- Chronic obstructive pulmonary diseases, Vol.10(3), pp.234-247
- DOI
- 10.15326/jcopdf.2022.0378
- PMID
- 37199732
- PMCID
- PMC10484485
- ISSN
- 2372-952X
- eISSN
- 2372-952X
- Grant note
- HHSN268200900017C / NHLBI NIH HHS HHSN268200900016C / NHLBI NIH HHS HHSN268200900019C / NHLBI NIH HHS HHSN268200900020C / NHLBI NIH HHS HHSN268200900018C / NHLBI NIH HHS U24 HL141762 / NHLBI NIH HHS HHSN268200900014C / NHLBI NIH HHS U01 HL137880 / NHLBI NIH HHS HHSN268200900015C / NHLBI NIH HHS HHSN268200900013C / NHLBI NIH HHS
- Language
- English
- Electronic publication date
- 05/16/2023
- Date published
- 2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Internal Medicine
- Record Identifier
- 9984410799702771
Metrics
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