Impact of Mood on Endothelial Function and Arterial Stiffness in Bipolar Disorder

Samantha L Schmitz; Oluchi J Abosi; Jane E Persons; Christine A Sinkey; Jess G Fiedorowicz

doi:10.4103/hm.hm_20_19

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Impact of Mood on Endothelial Function and Arterial Stiffness in Bipolar Disorder

Journal article

Open access

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Impact of Mood on Endothelial Function and Arterial Stiffness in Bipolar Disorder

Samantha L Schmitz, Oluchi J Abosi, Jane E Persons, Christine A Sinkey and Jess G Fiedorowicz

Heart and mind (Mumbai, India), Vol.2(3), pp.78-84

07/2018

DOI: 10.4103/hm.hm_20_19

PMCID: PMC6812514

PMID: 31650094

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Abstract

Previous research in bipolar disorder demonstrates greater than expected vascular dysfunction later in the course of illness, proportionate to the cumulative burden of mood symptoms. However, little is known about the effect of acute mood states on vascular function. Here we examine the relation between vascular function and mood state in individuals with bipolar disorder. This prospective study followed 40 individuals with bipolar disorder for up to 6 months. Participants were assessed for mood state and vascular function at baseline, 2 weeks, and 6 months. Mood state was determined using clinician-administered Montgomery-Åsberg Depression Rating Scale and Young Mania Rating Scale. Vascular function was assessed by flow-mediated dilation (FMD) of the brachial artery, forearm vascular resistance (FVR), and arterial stiffness. Participants had a mean age of 30.1 years and 75% were male. Primary outcome measures FMD and nitroglycerine-mediated dilation were not found to have statistically significant associations with depressive or manic symptoms. In unadjusted models, higher manic symptoms were significantly associated with increased FVR nitroprusside-mediated dilation and diastolic blood pressure. In adjusted models, higher depressive symptoms were significantly associated with increases in augmentation index adjusted for heart rate of 75 bpm, and higher manic symptoms remained associated with increases in diastolic blood pressure. FMD may have limited sensitivity as a biomarker for measuring short-term effects of mood state. Longer-term prospective studies are needed to clarify the temporal relation between chronic mood symptoms and vascular function in bipolar disorder.

arterial stiffness

Bipolar disorder

cardiovascular risk

endothelial dysfunction

Details

Title: Subtitle: Impact of Mood on Endothelial Function and Arterial Stiffness in Bipolar Disorder
Creators: Samantha L Schmitz - Department of Psychiatry, The University of Iowa, Iowa City, Iowa, 52242
Oluchi J Abosi - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa, 52242
Jane E Persons - Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, 52242
Christine A Sinkey - Department of Ophthalmology, The University of Iowa, Iowa City, Iowa, 52242
Jess G Fiedorowicz - Iowa Neuroscience Institute, Obesity Research and Education Initiative The University of Iowa, Iowa City, Iowa, 52242
Resource Type: Journal article
Publication Details: Heart and mind (Mumbai, India), Vol.2(3), pp.78-84
DOI: 10.4103/hm.hm_20_19
PMID: 31650094
PMCID: PMC6812514
NLM abbreviation: Heart Mind (Mumbai)
ISSN: 2468-6476
eISSN: 2468-6484
Publisher: India
Grant note: P01 HL014388 / NHLBI NIH HHS UL1 TR002537 / NCATS NIH HHS U54 TR001356 / NCATS NIH HHS K23 MH083695 / NIMH NIH HHS
Language: English
Date published: 07/2018
Academic Unit: Psychiatry; Epidemiology; Iowa Neuroscience Institute
Record Identifier: 9984071793902771

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