Journal article
Impact of Neonatal Sertraline Exposure on the Post-Myocardial Infarction Outcomes of Adult Male Mice
Journal of cardiovascular pharmacology, Vol.62(5), pp.479-484
11/2013
DOI: 10.1097/FJC.0b013e3182a4db90
PMCID: PMC3902860
PMID: 23921310
Abstract
Neonatal exposure to a selective serotonin reuptake inhibitor (SSRI) leads to decreased left ventricular volumes and sympathetic activation in adult mice. We hypothesized this neonatal SSRI exposure-induced small left heart syndrome would increase post-myocardial infarction morbidity and mortality. C57BL/6 mice received saline or sertraline (5 mg/kg IP) on post-natal days 1–14. At 5 months, male mice underwent coronary artery ligation and were monitored by radiotelemetry until death or 4 weeks post-ligation. Following ligation, SSRI exposed mice had increased heart rates (SSRI 516 ± 13 bpm, control 470 ± 15 bpm, p<0.05). SSRI-exposed mice had significant reductions in left ventricular systolic volumes both before and after coronary ligation (SSRI: baseline 20 ± 3 µL, post-MI 37 ± 10 µL; control: baseline 30 ± 3 µL, post-MI 65 ± 23 µL). Post-MI echocardiography showed significantly decreased ejection fraction in control mice (baseline 60 ± 4%, post-MI 41 ± 2%, p <0.01) but not SSRI-exposed mice (baseline 65 ± 3%, post-MI 53 ± 7%). Neonatal SSRI exposure did not significantly alter post-MI survival. We conclude that the preexisting SSRI-induced small left heart syndrome may provide protection from post-MI ventricular dilation.
Details
- Title: Subtitle
- Impact of Neonatal Sertraline Exposure on the Post-Myocardial Infarction Outcomes of Adult Male Mice
- Creators
- Sarah E Haskell - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IowaVeronica A Peotta - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IowaBenjamin E Reinking - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IowaGregory M Hermann - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IowaRobert D Roghair - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of cardiovascular pharmacology, Vol.62(5), pp.479-484
- DOI
- 10.1097/FJC.0b013e3182a4db90
- PMID
- 23921310
- PMCID
- PMC3902860
- NLM abbreviation
- J Cardiovasc Pharmacol
- ISSN
- 0160-2446
- eISSN
- 1533-4023
- Grant note
- R01 HL102659 || HL / National Heart, Lung, and Blood Institute : NHLBI T32 HL007121 || HL / National Heart, Lung, and Blood Institute : NHLBI
- Language
- English
- Date published
- 11/2013
- Academic Unit
- Critical Care; Cardiology; Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984093362402771
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