Impact of Nuclear Interleukin-1 Alpha and EGFR Expression on Recurrence and Survival Outcomes in Oral Squamous Cell Carcinomas

Anand Rajan; Katherine N Gibson-Corley; Allen B Choi; Georgina K Ofori-Amanfo; Patrick Ten Eyck; Madelyn Espinosa-Cotton; Steven M Sperry; Andrean L Simons

doi:10.1155/2019/5859680

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Impact of Nuclear Interleukin-1 Alpha and EGFR Expression on Recurrence and Survival Outcomes in Oral Squamous Cell Carcinomas

Journal article

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Impact of Nuclear Interleukin-1 Alpha and EGFR Expression on Recurrence and Survival Outcomes in Oral Squamous Cell Carcinomas

Anand Rajan, Katherine N Gibson-Corley, Allen B Choi, Georgina K Ofori-Amanfo, Patrick Ten Eyck, Madelyn Espinosa-Cotton, Steven M Sperry and Andrean L Simons

Journal of oncology, Vol.2019, 5859680

06/19/2019

DOI: 10.1155/2019/5859680

PMCID: PMC6607721

PMID: 31320902

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Abstract

Interleukin-1 alpha (IL-1α) is a pleiotropic cytokine involved in inflammation and immune response and is upregulated in many solid tumors including head and neck squamous cell carcinomas. Although IL-1α expression is generally associated with poor prognosis, the implications of the subcellular localization of IL-1α expression in patient outcomes are poorly understood. This study is aimed at investigating the prognostic value of nuclear and cytoplasmic immunohistochemical IL-1α expression in oral squamous cell carcinomas (OSCCs). Tissue microarrays containing 146 OSCCs were analyzed for IL-1α and epidermal growth factor receptor (EGFR) expression by immunohistochemistry. IL-1α and EGFR expression scores were correlated with clinicopathological parameters and survival outcomes. IL-1α expression was observed in the nuclear and/or cytoplasmic compartments in 98% of evaluable tumors and 78% of tumors expressed IL-1α in both compartments. There were no differences observed in overall survival or progression-free survival between high, moderate, or negative IL-1α nuclear/cytoplasmic expression scores. When IL-1α nuclear/cytoplasmic expression scores were stratified by positive or negative EGFR expression, tumors with a combined EGFR-positive and high nuclear IL-1α expression profile were significantly more likely to possess perineural invasion and were significantly associated with a high risk of tumor recurrence and worse progression-free survival compared to all other EGFR and combined IL-1α/EGFR expression profiles. Altogether, nuclear IL-1α expression may enhance the prognostic value of EGFR in OSCC and warrants further study as a prognostic biomarker for recurrence.

Details

Title: Subtitle: Impact of Nuclear Interleukin-1 Alpha and EGFR Expression on Recurrence and Survival Outcomes in Oral Squamous Cell Carcinomas
Creators: Anand Rajan - University of Iowa Hospitals and Clinics
Katherine N Gibson-Corley - University of Iowa Hospitals and Clinics
Allen B Choi - University of Iowa Hospitals and Clinics
Georgina K Ofori-Amanfo - University of Iowa Hospitals and Clinics
Patrick Ten Eyck - University of Iowa Hospitals and Clinics
Madelyn Espinosa-Cotton - University of Iowa Hospitals and Clinics
Steven M Sperry - University of Iowa Hospitals and Clinics
Andrean L Simons - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: Journal of oncology, Vol.2019, 5859680
DOI: 10.1155/2019/5859680
PMID: 31320902
PMCID: PMC6607721
NLM abbreviation: J Oncol
ISSN: 1687-8450
eISSN: 1687-8450
Grant note: name: Department of Pathology and National Institutes of Health, award: R01DE024550, UL1TR002537
Language: English
Date published: 06/19/2019
Academic Unit: Oral Pathology, Radiology and Medicine; The University of Iowa Institute for Vision Research; Pathology; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Surgery; Radiation Oncology; Ophthalmology and Visual Sciences
Record Identifier: 9984186531902771

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