Journal article
Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy
Pediatric cardiology, Vol.40(6), pp.1253-1257
08/01/2019
DOI: 10.1007/s00246-019-02145-9
PMID: 31263917
Abstract
Obesity is associated with additional left ventricular hypertrophy (LVH) in adults with hypertrophic cardiomyopathy (HCM). It is not known whether obesity can lead to further LVH in children with HCM. Echocardiographic LV dimensions were determined in 504 children with HCM. Measurements of interventricular septal thickness (IVST) and posterior wall thickness (PWT), and patients' weight and height were recorded. Obesity was defined as a body mass index (BMI) >= 99th percentile for age and sex. IVST data was available for 498 and PWT data for 484 patients. Patient age ranged from 2 to 20 years (mean +/- SD, 12.5 +/- 3.9) and 340 (68%) were males. Overall, patient BMI ranged from 7 to 50 (22.7 +/- 6.1). Obesity (BMI 18-50, mean 29.1) was present in 140 children aged 2-19.6 (11.3 +/- 4.1). The overall mean IVST was 20.5 +/- 9.6 mm and the overall mean PWT was 11.0 +/- 8.4 mm. The mean IVST in the obese patients was 21.6 +/- 10.0 mm and mean PWT was 13.3 +/- 14.7 mm. The mean IVST in the non-obese patients was 20.1 +/- 9.5 mm and mean PWT was 10.4 +/- 4.3 mm. Obesity was not significantly associated with IVST (p = 0.12), but was associated with increased PWT (0.0011). Obesity is associated with increased PWT but not IVST in children with HCM. Whether obesity and its impact on LVH influences clinical outcomes in children with HCM needs to be studied.
Details
- Title: Subtitle
- Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy
- Creators
- Seshadri Balaji - Oregon Health & Science UniversityMichael P. DiLorenzo - Children's Hospital of PhiladelphiaFrank A. Fish - Vanderbilt UniversitySusan P. Etheridge - University of UtahPeter F. Aziz - Cleveland ClinicMark W. Russell - University of Michigan–Ann ArborSvjetlana Tisma - Children's Mercy HospitalAndreas Pflaumer - Royal Children's HospitalNarayanswami Sreeram - University of ColognePeter Kubus - University Hospital in MotolIan H. Law - University of IowaMichal J. Kantoch - University of AlbertaNaomi J. Kertesz - Nationwide Children's HospitalMargaret Strieper - Sibley Heart Center, Atlanta, GA, USA.Christopher C. Erickson - Children's Hospital of Omaha, Omaha, NE, USAJeremy P. Moore - University of California, Los AngelesStephanie J. Nakano - University of Colorado BoulderHarinder R. Singh - Children's Hospital of San AntonioPhilip Chang - APLA HealthMitchell Cohen - Phoenix Children's HospitalAnne Fournier - Université de MontréalMaria V. Ilina - Royal Children's Glasgow, Glasgow, UK.Richard T. Smith - Carolinas Healthcare SystemFrank Zimmerman - Advocate Hospital Chicago, Chicago, IL, USA.Michaela Horndasch - Deutsches Herzzentrum MünchenWalter Li - University of California, San FranciscoAnjan Batra - University of California, IrvineLeonardo Liberman - Columbia UniversityRobert Hamilton - Hospital for Sick ChildrenChristopher M. Janson - Montefiore HospitalShubhayan Sanatani - University of British ColumbiaIlana Zeltser - The University of Texas Southwestern Medical CenterGeorge McDaniel - University of VirginiaAndrew D. Blaufox - Hofstra UniversityJason M. Garnreiter - Saint Louis UniversityHannah Katcoff - Children's Hospital of PhiladelphiaMaully Shah - Children's Hospital of Philadelphia
- Resource Type
- Journal article
- Publication Details
- Pediatric cardiology, Vol.40(6), pp.1253-1257
- Publisher
- Springer Nature
- DOI
- 10.1007/s00246-019-02145-9
- PMID
- 31263917
- ISSN
- 0172-0643
- eISSN
- 1432-1971
- Number of pages
- 5
- Grant note
- CR-1651 / Medtronic
- Language
- English
- Date published
- 08/01/2019
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984354048202771
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