Impact of PET/CT on Staging and Treatment of Advanced Head and Neck Squamous Cell Carcinoma

Jeffery B Jorgensen; Russell B Smith; Andrew Coughlin; William C Spanos; Michele M Lohr; Steven M Sperry; Oleg Militsakh; Robert P Zitsch III; Bevan Yueh; Laura M Dooley; Aru Panwar; Tabitha L I Galloway; Nitin A Pagedar

doi:10.1177/0194599818794479

Back

Impact of PET/CT on Staging and Treatment of Advanced Head and Neck Squamous Cell Carcinoma

Journal article

Open access

Peer reviewed

Impact of PET/CT on Staging and Treatment of Advanced Head and Neck Squamous Cell Carcinoma

Jeffery B Jorgensen, Russell B Smith, Andrew Coughlin, William C Spanos, Michele M Lohr, Steven M Sperry, Oleg Militsakh, Robert P Zitsch III, Bevan Yueh, Laura M Dooley, …

Otolaryngology-head and neck surgery, Vol.160(2), pp.261-266

02/2019

DOI: 10.1177/0194599818794479

PMCID: PMC8893991

PMID: 30126337

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/8893991View

Open Access

Abstract

To understand the effects of positron emission tomography/computed tomography (PET/CT) evaluation on patients with previously untreated head and neck squamous cell carcinoma (HNSCC) with clinical evidence of regional lymph node involvement. Prospective blinded study. Tertiary care cancer center. Informed consent was obtained and data collected from 52 consecutive previously untreated patients with HNSCC and clinical evidence of cervical metastasis. All patients underwent conventional evaluation for HNSCC and whole body PET/CT. Data were evaluated by 5 independent reviewers, who performed TNM staging per the American Joint Committee on Cancer (seventh edition) manual and proposed a treatment plan prior to viewing, and after reviewing, PET/CT. Cases where at least 3 of 5 reviewers agreed were considered significant. There were 0 patients for whom review of the PET/CT altered the T-class assessment (95% CI, 0-6.8), 12 (23.1%) for whom PET/CT altered N classification (95% CI, 12.5-34.5), and 2 (3.8%) for whom PET/CT altered the M classification (95% CI, 0.5-13.2). For 5 patients (9.6%), overall stage was altered per PET/CT review (95% CI, 3.2-21). For 3 patients (5.8%), PET/CT findings prompted reviewers to alter treatment recommendations (95% CI, 1.2-15.9). When added to more conventional patient evaluation, PET/CT results in changes to the TNM categories, but overall staging and treatment were less frequently affected. Whether PET/CT should be used routinely for patients with stage III and IV HNSCC is still subjective and merits further study.

Adult

Aged

Cohort Studies

Female

Head and Neck Neoplasms - diagnostic imaging

Head and Neck Neoplasms - mortality

Head and Neck Neoplasms - pathology

Head and Neck Neoplasms - surgery

Humans

Male

Middle Aged

Neoplasm Invasiveness

Neoplasm Staging

Positron Emission Tomography Computed Tomography - methods

Prognosis

Prospective Studies

Sensitivity and Specificity

Single-Blind Method

Squamous Cell Carcinoma of Head and Neck - diagnostic imaging

Squamous Cell Carcinoma of Head and Neck - mortality

Squamous Cell Carcinoma of Head and Neck - pathology

Squamous Cell Carcinoma of Head and Neck - surgery

Tertiary Care Centers

Details

Title: Subtitle: Impact of PET/CT on Staging and Treatment of Advanced Head and Neck Squamous Cell Carcinoma
Creators: Jeffery B Jorgensen - University of Missouri
Russell B Smith - The University of Texas MD Anderson Cancer Center
Andrew Coughlin - University of Nebraska Medical Center
William C Spanos - Sanford Health
Michele M Lohr - Sanford Health
Steven M Sperry - University of Iowa
Oleg Militsakh - University of Nebraska Medical Center
Robert P Zitsch III - University of Missouri
Bevan Yueh - University of Minnesota
Laura M Dooley - University of Missouri
Aru Panwar - University of Nebraska Medical Center
Tabitha L I Galloway - University of Missouri
Nitin A Pagedar - University of Iowa
Resource Type: Journal article
Publication Details: Otolaryngology-head and neck surgery, Vol.160(2), pp.261-266
DOI: 10.1177/0194599818794479
PMID: 30126337
PMCID: PMC8893991
NLM abbreviation: Otolaryngol Head Neck Surg
ISSN: 0194-5998
eISSN: 1097-6817
Grant note: R01 DE026125 / NIDCR NIH HHS P20 RR024219 / NCRR NIH HHS R01 DE029524 / NIDCR NIH HHS
Language: English
Date published: 02/2019
Academic Unit: Otolaryngology
Record Identifier: 9984311439802771

Metrics

7 Record Views

10 Times Cited - Web of Science

See more details