Journal article
Impact of SAMMPRIS on the future of intracranial atherosclerotic disease management: polling results from the ICAD symposium at the International Stroke Conference
Journal of neurointerventional surgery, Vol.6(3), pp.225-230
04/2014
DOI: 10.1136/neurintsurg-2013-010667
PMID: 23563478
Abstract
Objective There are few data regarding the effect of the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial results on the management of intracranial atherosclerotic disease (ICAD). We sought to understand the impact of the SAMMPRIS trial on current ICAD clinical practices and future trial design. Methods During the ICAD symposium at the 2012 International Stroke Conference, electronic data were collected regarding attendees’ clinical management of ICAD and opinions on the feasibility of future trials post-SAMMPRIS. Results 217 attendees from different specialties, including neurologists (57%), neurointerventionalists (9%) and neurosurgeons (5%), participated in the session. The majority of respondents (77%) indicated that the results of SAMMPRIS have impacted their consideration for intracranial stenting. Post-SAMMPRIS, 84% selected ‘SAMMPRIS-style’ medical management for the treatment of ICAD. For patients with ICAD who failed aggressive medical therapy, 82% would consider an alternative approach to continuing medical therapy (30% considered clinical trial enrollment, 28% suggested angioplasty and stenting and 24% angioplasty). The majority of participants (85%) were willing to randomize patients with symptomatic ICAD in future trials. For the next ICAD trial, 29% indicated that angioplasty alone should be compared with aggressive medical therapy. Conclusions Our polling results suggest that the SAMMPRIS trial has had an impact on the current treatment of ICAD. Treatment of patients who failed medical therapy varied widely from aggressive medical therapy to balloon angioplasty, stenting or enrollment in future clinical trials. The willingness to continue clinical trials and randomize patients supports the need for future ICAD studies.
Details
- Title: Subtitle
- Impact of SAMMPRIS on the future of intracranial atherosclerotic disease management: polling results from the ICAD symposium at the International Stroke Conference
- Creators
- Osama O Zaidat - Department of Radiology, Medical College of Wisconsin/Froedtert Hospital, Milwaukee, Wisconsin, USAAlicia C Castonguay - Department of Neurology, Medical College of Wisconsin/Froedtert Hospital, Milwaukee, Wisconsin, USAThanh N Nguyen - Departments of Neurology, Neurosurgery, Radiology, Boston University School of Medicine, Boston, Massachusetts, USAKyra J Becker - Department of Neurology, University of Washington School of Medicine, Harborview Medical Center, Seattle, Washington, USAColin P Derdeyn - Center for Stroke and Cerebrovascular Disease, Washington University School of Medicine, St. Louis, Missouri, USAPeter K Nelson - Departments of Radiology and Neurosurgery, New York University Medical Center, New York, New York, USAPierre Amarenco - Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, FranceThomas G Brott - Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
- Resource Type
- Journal article
- Publication Details
- Journal of neurointerventional surgery, Vol.6(3), pp.225-230
- DOI
- 10.1136/neurintsurg-2013-010667
- PMID
- 23563478
- ISSN
- 1759-8478
- eISSN
- 1759-8486
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020749402771
Metrics
17 Record Views