Impact of Sleep Disturbance, Physical Function, Depression and Anxiety on Male Lower Urinary Tract Symptoms: Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)

Alexander P Glaser; Sarah Mansfield; Abigail R Smith; Brian T Helfand; H Henry Lai; Aruna Sarma; Claire C Yang; Michelle Taddeo; J Quentin Clemens; Anne P Cameron; Kathryn E Flynn; Victor Andreev; Matthew O Fraser; Bradley A Erickson; Ziya Kirkali; James W Griffith; Lower Urinary Tract Dysfunction Research Network (LURN) Study Group

doi:10.1097/JU.0000000000002493

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Impact of Sleep Disturbance, Physical Function, Depression and Anxiety on Male Lower Urinary Tract Symptoms: Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)

Journal article

Peer reviewed

Impact of Sleep Disturbance, Physical Function, Depression and Anxiety on Male Lower Urinary Tract Symptoms: Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)

Alexander P Glaser, Sarah Mansfield, Abigail R Smith, Brian T Helfand, H Henry Lai, Aruna Sarma, Claire C Yang, Michelle Taddeo, J Quentin Clemens, Anne P Cameron, …

The Journal of urology, Vol.208(1), pp.155-163

07/2022

DOI: 10.1097/JU.0000000000002493

PMCID: PMC9336513

PMID: 35212573

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https://www.ncbi.nlm.nih.gov/pmc/articles/9336513View

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Abstract

The impact of nonurological factors on male lower urinary tract symptoms (LUTS) remains unclear. We investigated cross-sectional and longitudinal associations among anxiety, depression, physical function, sleep quality and urinary symptom subdomains. Data from 518 men in the LURN (Symptoms of Lower Urinary Tract Dysfunction Research Network) study were analyzed to identify associations between Patient-Reported Outcomes Measurement Information System® (PROMIS®) depression, anxiety, sleep disturbance and physical function measures and LUTS subdomains, as derived from the American Urological Association Symptom Index and LUTS Tool. Multivariable linear regression was used to assess the relationships between PROMIS measures and LUTS subdomains at baseline and at 3- and 12-month followup. Baseline depression and anxiety were associated with urinary incontinence (p <0.001), voiding symptoms (p <0.001) and quality of life (p=0.002), whereas baseline sleep disturbance was associated with voiding and storage symptoms and quality of life (p <0.001 for all). Urinary symptom severity improved in all subdomains at 3 and 12 months. Similar associations between PROMIS measures and LUTS subdomains were observed at all time points, but baseline depression, anxiety, sleep disturbance and physical function measures were not associated with longitudinal trajectories of LUTS. Urinary symptom subdomains are independently associated with modifiable clinical variables including sleep quality and depression at all time points, but these variables do not predict the degree of improvement in LUTS following urological evaluation and treatment over the medium term. Bidirectional assessment and randomized experiments may improve our understanding of these relationships.

Quality of Life

anxiety

patient reported outcome measures

depression

lower urinary tract symptoms

Details

Title: Subtitle: Impact of Sleep Disturbance, Physical Function, Depression and Anxiety on Male Lower Urinary Tract Symptoms: Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)
Creators: Alexander P Glaser - NorthShore University HealthSystem
Sarah Mansfield - Arbor Research Collaborative for Health
Abigail R Smith - Arbor Research Collaborative for Health
Brian T Helfand - NorthShore University HealthSystem
H Henry Lai - Washington University in St. Louis
Aruna Sarma - University of Michigan
Claire C Yang - University of Washington
Michelle Taddeo - Northwestern University
J Quentin Clemens - University of Michigan
Anne P Cameron - University of Michigan
Kathryn E Flynn - Medical College of Wisconsin
Victor Andreev - Arbor Research Collaborative for Health
Matthew O Fraser - Duke University
Bradley A Erickson - University of Iowa
Ziya Kirkali - National Institute of Diabetes and Digestive and Kidney Diseases
James W Griffith - Northwestern University
Lower Urinary Tract Dysfunction Research Network (LURN) Study Group
Resource Type: Journal article
Publication Details: The Journal of urology, Vol.208(1), pp.155-163
DOI: 10.1097/JU.0000000000002493
PMID: 35212573
PMCID: PMC9336513
NLM abbreviation: J Urol
ISSN: 0022-5347
eISSN: 1527-3792
Language: English
Date published: 07/2022
Academic Unit: Urology
Record Identifier: 9984319968202771

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