Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry

Giuseppe De Luca; Magdy Algowhary; Berat Uguz; Dinaldo C. Oliveira; Vladimir Ganyukov; Zan Zimbakov; Miha Cercek; Lisette Okkels Jensen; Poay Huan Loh; Lucian Calmac; Gerard Roura Ferrer; Alexandre Quadros; Marek Milewski; Fortunato Scotto D'Uccio; Clemens von Birgelen; Francesco Versaci; Jurrien Ten Berg; Gianni Casella; Aaron Wong Sung Lung; Petr Kala; Jose Luis Diez Gil; Xavier Carrillo; Maurits Dirksen; Victor M. Becerra-Munoz; Michael Kang-Yin Lee; Dafsah Arifa Juzar; Rodrigo de Moura Joaquim; Roberto Paladino; Davor Milicic; Periklis Davlouros; Nikola Bakraceski; Filippo Zilio; Luca Donazzan; Adriaan Kraaijeveld; Gennaro Galasso; Lux Arpad; Marinucci Lucia; Guiducci Vincenzo; Maurizio Menichelli; Alessandra Scoccia; Aylin Hatice Yamac; Kadir Ugur Mert; Xacobe Flores Rios; Tomas Kovarnik; Michal Kidawa; Jose Moreu; Flavien Vincent; Enrico Fabris; Inigo Lozano Martinez-Luengas; Marco Boccalatte; Francisco Bosa Ojeda; Carlos Arellano-Serrano; Gianluca Caiazzo; Giuseppe Cirrincione; Hsien-Li Kao; Juan Sanchis Fores; Luigi Vignali; Helder Pereira; Stephane Manzo; Santiago Ordonez; Alev Arat Ozkan; Bruno Scheller; Heidi Lehtola; Rui Teles; Christos Mantis; Ylitalo Antti; Joao Antonio Brum Silveira; Rodrigo Zoni; Ivan Bessonov; Stefano Savonitto; George Kochiadakis; Dimitrios Alexopulos; Carlos E. Uribe; John Kanakakis; Benjamin Faurie; Gabriele Gabrielli; Alejandro Gutierrez Barrios; Juan Pablo Bachini; Alex Rocha; Frankie Chor-Cheung Tam; Alfredo Rodriguez; Antonia Anna Lukito; Veauthyelau Saint-Joy; Gustavo Pessah; Andrea Tuccillo; Giuliana Cortese; Guido Parodi; Mohamed Abed Bouraghda; Elvin Kedhi; Pablo Lamelas; Harry Suryapranata; Matteo Nardin; Monica Verdoia

doi:10.3390/jcm11226722

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Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry

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Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry

Giuseppe De Luca, Magdy Algowhary, Berat Uguz, Dinaldo C. Oliveira, Vladimir Ganyukov, Zan Zimbakov, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, …

Journal of clinical medicine, Vol.11(22), p.6722

11/13/2022

DOI: 10.3390/jcm11226722

PMCID: PMC9698021

PMID: 36431198

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Abstract

The so-called "smoking paradox", conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking history.

General & Internal Medicine

Life Sciences & Biomedicine

Medicine, General & Internal

Science & Technology

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Title: Subtitle: Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry
Creators: Giuseppe De Luca - University of Sassari
Magdy Algowhary - Assiut University
Berat Uguz - Bursa Technical University
Dinaldo C. Oliveira - Univ Fed Pernambuco, Ctr PROCAPE, Pronto de Socorro Cardiol Prof Luis Tavares, BR-50000000 Recife, PE, Brazil
Vladimir Ganyukov - Kemerovo State University
Zan Zimbakov - Saints Cyril and Methodius University of Skopje
Miha Cercek - Ljubljana University Medical Centre
Lisette Okkels Jensen - Odense University Hospital
Poay Huan Loh - National University Hospital
Lucian Calmac - Clinical Emergency Hospital Bucharest
Gerard Roura Ferrer - Bellvitge University Hospital
Alexandre Quadros - Inst Cardiol Rio Grande do Sul, BR-9000000 Porto Alegre, RS, Brazil
Marek Milewski - Medical University of Silesia
Fortunato Scotto D'Uccio - Osped Mare, Div Cardiol, I-00156 Naples, Italy
Clemens von Birgelen - Medisch Spectrum Twente
Francesco Versaci - Ospedale Santa Maria Goretti
Jurrien Ten Berg - St Antonius Hosp, Div Cardiol, NL-3434 Nieuwegein, Netherlands
Gianni Casella - Ospedale Maggiore Carlo Alberto Pizzardi
Aaron Wong Sung Lung - National Heart Centre Singapore
Petr Kala - Masaryk University
Jose Luis Diez Gil - Hospital Universitari i Politècnic La Fe
Xavier Carrillo - Hospital Universitari Germans Trias i Pujol
Maurits Dirksen - Northwest Hospital
Victor M. Becerra-Munoz - Hosp Clin Univ Virgen de la Victoria, Cardiol, Malaga 29000, Spain
Michael Kang-Yin Lee - Queen Elizabeth Hospital
Dafsah Arifa Juzar - University of Indonesia
Rodrigo de Moura Joaquim - Inst Cardiol Santa Catarina Praia Comprida, BR-88100000 Sao Jose, Brazil
Roberto Paladino - Clin Villa dei Fiori, Div Cardiol, I-80011 Acerra, Italy
Davor Milicic - University Hospital Centre Zagreb
Periklis Davlouros - General University Hospital of Patras
Nikola Bakraceski - Ctr Cardiovasc Dis, Ohrid 6000, North Macedonia
Filippo Zilio - Ospedale Santa Chiara
Luca Donazzan - Ospedale di Bolzano
Adriaan Kraaijeveld - University Medical Center Utrecht
Gennaro Galasso - Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
Lux Arpad - Maastricht University
Marinucci Lucia - Azienda Osped Osped Riuniti Marche Nord, Div Cardiol, I-61121 Pesaro, Italy
Guiducci Vincenzo - AUSL IRCCS Reggio Emilia, Div Cardiol, I-42121 Reggio Emilia, Italy
Maurizio Menichelli - Osped F Spaziani, Div Cardiol, I-03100 Frosinone, Italy
Alessandra Scoccia - Ospedale Sant'Anna
Aylin Hatice Yamac - Bezmiâlem Vakıf Üniversitesi
Kadir Ugur Mert - Eskişehir Osmangazi University
Xacobe Flores Rios - Complexo Hospitalario Universitario A Coruña
Tomas Kovarnik - General University Hospital in Prague
Michal Kidawa - Med Univ Lodz, Cent Hosp, PL-90008 Lodz, Poland
Jose Moreu - Complejo Hospitalario Universitario de Toledo
Flavien Vincent - Centre Hospitalier Universitaire de Lille
Enrico Fabris - Azienda Ospedaliero Universitaria Ospedali Riuniti
Inigo Lozano Martinez-Luengas - Hosp Cabuenes, Div Cardiol, Gijon 33201, Spain
Marco Boccalatte - Ospedale Santa Maria
Francisco Bosa Ojeda - Hospital Universitario de Canarias
Carlos Arellano-Serrano - Hospital Universitario Puerta de Hierro Majadahonda
Gianluca Caiazzo - Azienda Ospedaliera S.Giuseppe Moscati
Giuseppe Cirrincione - Azienda di Rilievo Nazionale ed Alta Specializzazione
Hsien-Li Kao - Natl Taiwan Univ Hosp, Dept Internal Med, Cardiol Div, Taipei 8865600, Taiwan
Juan Sanchis Fores - Hospital Clínico Universitario de Valencia
Luigi Vignali - Azienda Osped Sanitaria, Intervent Cardiol Unit, I-43121 Parma, Italy
Helder Pereira - Hospital Garcia de Orta
Stephane Manzo - Assistance Publique – Hôpitaux de Paris
Santiago Ordonez - Instituto Cardiovascular de Buenos Aires
Alev Arat Ozkan - Instanbul Univ, Cardiol Inst, TR-34000 Istanbul, Turkey
Bruno Scheller - Saarland University
Heidi Lehtola - Oulu University Hospital
Rui Teles - Hospital de Santa Cruz
Christos Mantis - Kontantopoul Hosp, Div Cardiol, Athens 10431, Greece
Ylitalo Antti - Turku PET Centre
Joao Antonio Brum Silveira - Hosp Santo Antonio, Div Cardiol, P-4099001 Porto, Portugal
Rodrigo Zoni - University of Tyumen
Ivan Bessonov - Inst Cardiol Corrientes Juana F Cabral, Dept Teaching & Res, Corrientes W3400CDS, Corrientes, Argentina
Stefano Savonitto - Alessandro Manzoni Hospital
George Kochiadakis - University Hospital of Heraklion
Dimitrios Alexopulos - University General Hospital Attikon
Carlos E. Uribe - Clínica CES
John Kanakakis - Alexandra Hospital
Benjamin Faurie - Groupe Hospitalier Mutualiste de Grenoble
Gabriele Gabrielli - Azienda Ospedaliero Universitaria Ospedali Riuniti
Alejandro Gutierrez Barrios - Hospital Universitario Puerta del Mar
Juan Pablo Bachini - Inst Cardiol Integral, Montevideo 11700, Uruguay
Alex Rocha - Instituto Nacional de Investigación Agropecuaria
Frankie Chor-Cheung Tam - Queen Mary Hospital
Alfredo Rodriguez - Sanatorio Otamendi y Miroli
Antonia Anna Lukito - Pelita Harapan University
Veauthyelau Saint-Joy - Ctr Hosp Antibes Juan Les Pins, Cardiol, F-06600 Antibes, France
Gustavo Pessah - Servicio Diabetología Hospital Córdoba
Andrea Tuccillo - Osped Mare, Div Cardiol, I-00156 Naples, Italy
Giuliana Cortese - University of Padua
Guido Parodi - Azienda Ospedaliera S.Maria
Mohamed Abed Bouraghda - Blida Univ Hosp, Div Cardiol, Blida 09000, Algeria
Elvin Kedhi - Université Libre de Bruxelles
Pablo Lamelas - Instituto Cardiovascular de Buenos Aires
Harry Suryapranata - Radboud University Nijmegen
Matteo Nardin - Osped Riuniti, Dept Internal Med, I-25121 Brescia, Italy
Monica Verdoia - ASL Biella, Div Cardiol, Osped Infermi, I-13900 Biella, Italy
Resource Type: Journal article
Publication Details: Journal of clinical medicine, Vol.11(22), p.6722
Publisher: Mdpi
DOI: 10.3390/jcm11226722
PMID: 36431198
PMCID: PMC9698021
ISSN: 2077-0383
eISSN: 2077-0383
Number of pages: 13
Language: English
Date published: 11/13/2022
Academic Unit: Electrical and Computer Engineering
Record Identifier: 9984627216002771

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