Impact of Treatment Time on Outcome for Resected Head and Neck Squamous Cell Carcinoma by HPV Status

John M Watkins; Anthony N Snow; Carryn M Anderson; John M Buatti; Nicholas S Andresen; Nitin A Pagedar; Rodrigo Bayon; Sarah L Mott

doi:10.31487/j.COR.2020.02.09

Back

Impact of Treatment Time on Outcome for Resected Head and Neck Squamous Cell Carcinoma by HPV Status

Journal article

Open access

Impact of Treatment Time on Outcome for Resected Head and Neck Squamous Cell Carcinoma by HPV Status

John M Watkins, Anthony N Snow, Carryn M Anderson, John M Buatti, Nicholas S Andresen, Nitin A Pagedar, Rodrigo Bayon and Sarah L Mott

Clinical Oncology and Research, pp.1-7

02/29/2020

DOI: 10.31487/j.COR.2020.02.09

Files and links (1)

url

https://doi.org/10.31487/j.COR.2020.02.09View

Published (Version of record) Open Access

Abstract

Background and Purpose: Prior investigations have demonstrated an inverse correlation between the interval from resection of head and neck squamous cell carcinoma (HNSCC) to radiotherapy (RT) completion (overall treatment time; OTT) and disease control. However, the importance of OTT in human papillomavirus (HPV)-associated HNSCC remains to be determined. This study evaluates whether OTT remains independently associated with cancer control when evaluated by HPV association. Material and Methods: The data of HNSCC patients treated with curative-intent surgical resection followed by RT were collected. Univariable and multivariable analyses were used to assess the effects of HPV association and OTT. Results: From 2002-2014, 73 eligible patients were identified (36 HPV-associated). The median OTT was 94 days (range, 69-185, with no difference between HPV subgroups). At a median follow-up of 34.9 months (range, 2.6-162.2), 21 patients experienced disease failure, and 25 died. HPV-association was linked to improved disease-free survival (DFS), disease-specific survival (DFS), and overall survival (OS) by univariable and multivariable analyses. OTT was associated with improved DFS by univariable and multivariable analyses. Conclusion: OTT remains significantly associated with cancer control in the setting of HPV-associated disease. Efforts should be made to minimize the delay between resection and completion of RT for all HNSCC patients.

Details

Title: Subtitle: Impact of Treatment Time on Outcome for Resected Head and Neck Squamous Cell Carcinoma by HPV Status
Creators: John M Watkins
Anthony N Snow
Carryn M Anderson
John M Buatti
Nicholas S Andresen
Nitin A Pagedar
Rodrigo Bayon
Sarah L Mott
Resource Type: Journal article
Publication Details: Clinical Oncology and Research, pp.1-7
DOI: 10.31487/j.COR.2020.02.09
ISSN: 2613-4942
eISSN: 2613-4942
Language: English
Date published: 02/29/2020
Academic Unit: Pathology; Radiation Oncology; Neurosurgery; Otolaryngology
Record Identifier: 9984201422002771

Metrics

14 Record Views