Journal article
Impact of acute antioxidant administration on inflammation and vascular function in heart failure with preserved ejection fraction
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.317(5), pp.R607-R614
11/01/2019
DOI: 10.1152/ajpregu.00184.2019
PMCID: PMC6879844
PMID: 31483155
Abstract
Although it is now well established that heart failure with preserved ejection fraction (HFpEF) is associated with marked inflammation and a prooxidant state that is accompanied by vascular dysfunction, whether acute antioxidant (AO) administration can effectively target these disease-related decrements has not been evaluated. Thus, the present study sought to evaluate the efficacy of an acute over-the-counter AO cocktail (600 mg alpha-lipoic acid. 1.000 mg vitamin C. and 6(X) IU vitamin E) to mitigate inflammation and oxidative stress, and subsequently improve nitric oxide (NO) bioavailability and vascular function, in patients with HFpEF. Flow-mediated dilation (FMD) and reactive hyperemia (RH) were evaluated to assess conduit vessel and microvascular function, respectively, 90 min after administration of either placebo (PL) or AO in 16 patients with HFpEF (73 +/- 10 yr, EF 54-70%) using a double-blind, crossover design. Circulating biomarkers of inflammation (C-reactive protein, CRP), oxidative stress (malondialdehyde and protein carbonyl), free radical concentration (EPR spectroscopy), antioxidant capacity, ascorbate and NO bioavailability (plasma nitrate, NO3-, and nitrite, NO; were also assessed. FMD improved following AO administration (PL: 3.49 +/- 0.7%, AO: 5.83 +/- 1.0%), whereas RH responses were similar between conditions (PL: 428 +/- 51 mL, AO: 425 +/- 51 inL). AO administration decreased CRP (PL: 4,429 +/- 705 ng/mL, AO: 3,664 +/- 520 ng/mL) and increased ascorbate (PL: 30.0 +/- 2.9 mu g/mL, AO: 45.1 +/- 3.7 mu g/mL) and NO2- (PL: 182 +/- 21 nM. AO: 213 +/- 24 nM) but did not affect other biomarkers. Together, these data suggest that acute AO administration can exert anti-inflammatory effects and improve conduit artery vasodilation, but not microvascular function, in patients with HFpEF.
Details
- Title: Subtitle
- Impact of acute antioxidant administration on inflammation and vascular function in heart failure with preserved ejection fraction
- Creators
- Stephen M. Ratchford - Geriatric Research Education and Clinical CenterHeather L. Clifton - University of UtahJayson R. Gifford - Brigham Young UniversityD. Taylor LaSalle - University of UtahTaylor S. Thurston - University of UtahKanokwan Bunsawat - University of UtahJeremy K. Alpenglow - University of UtahRussell S. Richardson - University of UtahJosephine B. Wright - University of UtahJohn J. Ryan - University of UtahD. Walter Wray - University of Utah
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.317(5), pp.R607-R614
- DOI
- 10.1152/ajpregu.00184.2019
- PMID
- 31483155
- PMCID
- PMC6879844
- NLM abbreviation
- Am J Physiol Regul Integr Comp Physiol
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Publisher
- Amer Physiological Soc
- Number of pages
- 8
- Grant note
- 18POST33960192 / American Heart Association RX001311; RX001697; RX009275; CX001183 / U.S. Department of Veterans Affairs; US Department of Veterans Affairs HL-118313 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 11/01/2019
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9984948042902771
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