Journal article
Impact of binge drinking during college on resting state functional connectivity
Drug and alcohol dependence, Vol.227, pp.108935-108935
10/01/2021
DOI: 10.1016/j.drugalcdep.2021.108935
PMCID: PMC8464531
PMID: 34388578
Abstract
Aim: The current study examined the longitudinal effects of standard binge drinking (4+/5+ drinks for females/ males in 2 hours) and extreme binge drinking (8+/10+ drinks for females/males in 2 hours) on resting-state functional connectivity. Method: 119 college students (61 males) were recruited in groups of distinct bingeing patterns at baseline: nonbingeing controls, standard and extreme bingers. Resting-state scans were first obtained when participants were freshmen/sophomores and again approximately two years later. Associations between longitudinal bingeing (reported during this two-year gap) and network connectivity were examined. Network connectivity was calculated by aggregating all edges affiliated with the same network (an edge is a functional connection between two brain regions). The relationship between longitudinal bingeing and connectivity edges was also studied using connectome-based predictive modeling (CPM). Results: Greater standard bingeing was negatively associated with change in connectivity between Default Mode Network and Ventral Attention Network (DMN-VAN; False Discovery Rate corrected), controlling for initial binge groups, longitudinal network changes, motions, scanner, SES, sex, and age. The correlations between change in DMN-VAN connectivity and change in cognitive performance (Stroop, Digit Span, Letter Fluency, and Trail Making) were also tested, but the results were not significant. Lastly, CPM failed to identify a generalizable predictive model of longitudinal bingeing from change in connectivity edges. Conclusions: Binge drinking is associated with abnormality in networks implicated in attention and self-focused processes, which, in turn, have been implicated in rumination, craving, and relapse. More extensive alterations in functional connectivity might be observed with heavier or longer binge drinking pattern.
Details
- Title: Subtitle
- Impact of binge drinking during college on resting state functional connectivity
- Creators
- Tien T. Tong - University of IowaJatin G. Vaidya - Roy J. and Lucille A. Carver College of MedicineJohn R. Kramer - Roy J. and Lucille A. Carver College of MedicineSamuel Kuperman - Roy J. and Lucille A. Carver College of MedicineDouglas R. Langbehn - Roy J. and Lucille A. Carver College of MedicineDaniel S. O'Leary - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Drug and alcohol dependence, Vol.227, pp.108935-108935
- DOI
- 10.1016/j.drugalcdep.2021.108935
- PMID
- 34388578
- PMCID
- PMC8464531
- NLM abbreviation
- Drug Alcohol Depend
- ISSN
- 0376-8716
- eISSN
- 1879-0046
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: 1S10OD025025-01, 5R01AA021165
- Language
- English
- Date published
- 10/01/2021
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984293656402771
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