Journal article
Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults
The Journal of infectious diseases, Vol.210(8), pp.1270-1274
10/15/2014
DOI: 10.1093/infdis/jiu245
PMCID: PMC4271072
PMID: 24795475
Abstract
Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.
Details
- Title: Subtitle
- Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults
- Creators
- S Todd Callahan - Division of Adolescent and Young Adult Health, Department of Pediatrics Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TennesseeMark Wolff - EMMES Corp., Rockville, MarylandHeather R Hill - EMMES Corp., Rockville, MarylandKathryn M Edwards - Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TennesseeNIAID Vaccine and Treatment Evaluation Unit (VTEU) Pandemic H1N1 Vaccine Study Group
- Contributors
- Jack Stapleton (Contributor) - University of Iowa, Internal MedicineJeffrey Meier (Contributor) - University of Iowa, Internal Medicine
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.210(8), pp.1270-1274
- DOI
- 10.1093/infdis/jiu245
- PMID
- 24795475
- PMCID
- PMC4271072
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Grant note
- HHSN272200800002C / NIAID NIH HHS HHSN272200800001C / NIAID NIH HHS HHSN272200800002C / PHS HHS HHSN272200800004C / NIAID NIH HHS HHSN272200800001G / NIAID NIH HHS HHSN272200800001C / PHS HHS HHSN272200800001I / NIAID NIH HHS HHSN272200800013C / NIAID NIH HHS HHSN272200800013C / PHS HHS HHSN272200800001O / NIAID NIH HHS HHSN272200800004C / PHS HHS HHSN27220080000C / PHS HHS
- Language
- English
- Date published
- 10/15/2014
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Epidemiology; Internal Medicine
- Record Identifier
- 9984094370202771
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