Impact of bone events on survival in solitary bone plasmacytoma

Geovanne Pedro Mauro; Pedro Pereira Neffá; Rosangela Correa Villar; Gracia Aparecida Martinez; Heloísa de Andrade Carvalho

doi:10.1016/j.rpor.2020.04.002

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Impact of bone events on survival in solitary bone plasmacytoma

Journal article

Peer reviewed

Impact of bone events on survival in solitary bone plasmacytoma

Geovanne Pedro Mauro, Pedro Pereira Neffá, Rosangela Correa Villar, Gracia Aparecida Martinez and Heloísa de Andrade Carvalho

Reports of practical oncology and radiotherapy, Vol.25(3), pp.389-395

05/01/2020

DOI: 10.1016/j.rpor.2020.04.002

PMCID: PMC7171253

PMID: 32322178

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Abstract

Although much studied in multiple myeloma, bone events (BE) can also cause important morbidity in bone plasmacytoma patients. To our knowledge, the effect of BE on overall survival (OS) and progression to multiple myeloma free-survival (MPFS) also has never been studied. Fifty-nine patients treated from 2008 to 2017 were retrospectively assessed. All patients had histological proof of disease and were treated with radical radiotherapy (RT). Available clinical information for at least 6 months follow-up or until death had to be available. BE were described as one of the following events in the index bone: fractures, osteomyelitis, chronic pain, surgery or loss of limb function after RT. Mean age at diagnosis was 57.3 years (18–80); most male (67.8%). Mean OS, bone event free-survival (BEFS), local progression-free survival (LPFS) and MPFS were 41, 36, 37 and 19 months, respectively. There were 15 deaths. BEFS (p = 0.008) and age>55y (p = 0.044) were associated with MPFS. Only BEFS correlated with OS (p = 0.029). BE was independently associated with both MPFS and OS in multivariate analysis. BE and survival end-points were correlated. BE should be investigated in prospective trials.

Bone disease

Morbidity

Multiple myeloma progression

Plasmacytoma

Skeletal events

Details

Title: Subtitle: Impact of bone events on survival in solitary bone plasmacytoma
Creators: Geovanne Pedro Mauro - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Pedro Pereira Neffá - Instituto do Câncer do Estado de São Paulo
Rosangela Correa Villar - Centro Infantil Boldrini
Gracia Aparecida Martinez - Instituto do Câncer do Estado de São Paulo
Heloísa de Andrade Carvalho - Department of Radiology and Oncology, Instituto de Radiologia do Hospital das Clínicas, Medical School os Sao Paulo University, Brazil
Resource Type: Journal article
Publication Details: Reports of practical oncology and radiotherapy, Vol.25(3), pp.389-395
DOI: 10.1016/j.rpor.2020.04.002
PMID: 32322178
PMCID: PMC7171253
NLM abbreviation: Rep Pract Oncol Radiother
ISSN: 1507-1367
eISSN: 2083-4640
Publisher: Elsevier B.V
Number of pages: 7
Language: English
Date published: 05/01/2020
Academic Unit: Radiation Oncology
Record Identifier: 9984914018602771

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