Impact of chronic total occlusion on ventricular arrhythmia and mortality in ischaemic cardiomyopathy patient with implantable cardiac defibrillator: a meta-analysis

Wasawat Vutthikraivit; Pattara Rattanawong; Jakrin Kewcharoen; Chanavuth Kanitsoraphan; Pavida Pachariyanon; Sakolwan Suchartlikitwong; Saranapoom Klomjit; Pakpoom Tantrachoti

doi:10.1080/00015385.2018.1516268

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Impact of chronic total occlusion on ventricular arrhythmia and mortality in ischaemic cardiomyopathy patient with implantable cardiac defibrillator: a meta-analysis

Journal article

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Impact of chronic total occlusion on ventricular arrhythmia and mortality in ischaemic cardiomyopathy patient with implantable cardiac defibrillator: a meta-analysis

Wasawat Vutthikraivit, Pattara Rattanawong, Jakrin Kewcharoen, Chanavuth Kanitsoraphan, Pavida Pachariyanon, Sakolwan Suchartlikitwong, Saranapoom Klomjit and Pakpoom Tantrachoti

Acta Cardiologica, Vol.74(5), pp.395-402

09/03/2019

DOI: 10.1080/00015385.2018.1516268

PMID: 30328769

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Abstract

Background: Recent studies suggested that chronic total occlusion of the coronary artery increased risk of ventricular arrhythmia (VA) and all-cause mortality in ischaemic cardiomyopathy (ICM) patient who underwent implantable cardiac defibrillator (ICD) implantation. We aim to demonstrate an association between a presence of CTO and poor cardiovascular outcome in ICD implanted ICM patients. Objective: To examine the association between the presence of CTO and all-cause mortality in ICM with ICD implantation Methods: We comprehensively searched the databases of MEDLINE and EMBASE from inception to February 2018. The studies that reported appropriated shock and all-cause mortality in ICD implanted ICM patients, compared between patients with and without CTO of the coronary artery, were included for meta-analysis. Results: Five studies from 2015 to 2018 were included in this meta-analysis involving 1,095 subjects (505 CTO and 590 non-CTO). The presence of CTO was associated with increased incidence of VA (pooled risk ratio = 1.75, 95% confidence interval: 1.10-2.77, p = 0.01) and all-cause mortality (pooled risk ratio = 1.63, 95% confidence interval: 1.10-2.41, p = 0.001) in ICD implanted ICM patients. Conclusions: Presence of CTO of the coronary artery increased risk of VA and all-cause mortality in ICD implanted ICM patients up to 75% and 63%, respectively. Our study suggested that CTO is an independent predictor of unfavourable outcome and revascularised option should be considered in ICM patients with ICD.

Chronic total coronary occlusion

implantable cardioverter-defibrillator

ischaemic cardiomyopathy

mortality

ventricular arrhythmia

Details

Title: Subtitle: Impact of chronic total occlusion on ventricular arrhythmia and mortality in ischaemic cardiomyopathy patient with implantable cardiac defibrillator: a meta-analysis
Creators: Wasawat Vutthikraivit - Texas Tech University Health Sciences Center
Pattara Rattanawong - University of Hawaii System
Jakrin Kewcharoen - University of Hawaii System
Chanavuth Kanitsoraphan - University of Hawaii System
Pavida Pachariyanon - Texas Tech University Health Sciences Center
Sakolwan Suchartlikitwong - Texas Tech University Health Sciences Center
Saranapoom Klomjit - Texas Tech University Health Sciences Center
Pakpoom Tantrachoti - Texas Tech University Health Sciences Center
Resource Type: Journal article
Publication Details: Acta Cardiologica, Vol.74(5), pp.395-402
Publisher: Taylor & Francis
DOI: 10.1080/00015385.2018.1516268
PMID: 30328769
ISSN: 0001-5385
eISSN: 1784-973X
Language: English
Date published: 09/03/2019
Academic Unit: Internal Medicine
Record Identifier: 9984691514602771

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