Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitus

Eva Tsalikian; Nelly Mauras; Roy W Beck; William V Tamborlane; Kathleen F Janz; H Peter Chase; Tim Wysocki; Stuart A Weinzimer; Bruce A Buckingham; Craig Kollman; Dongyuan Xing; Katrina J Ruedy; Diabetes Research In Children Network Direcnet Study Group

doi:10.1016/j.jpeds.2005.04.065

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Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitus

Journal article

Peer reviewed

Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitus

Eva Tsalikian, Nelly Mauras, Roy W Beck, William V Tamborlane, Kathleen F Janz, H Peter Chase, Tim Wysocki, Stuart A Weinzimer, Bruce A Buckingham, Craig Kollman, …

The Journal of pediatrics, Vol.147(4), pp.528-534

10/2005

DOI: 10.1016/j.jpeds.2005.04.065

PMCID: PMC2258153

PMID: 16227041

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http://doi.org/10.1016/j.jpeds.2005.04.065View

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Abstract

To examine the effect of exercise on overnight hypoglycemia in children with type 1 diabetes mellitus (T1DM). At 5 clinical sites, 50 subjects with T1DM (age 11 to 17 years) were studied in a clinical research center on 2 separate days. One day included an afternoon exercise session on a treadmill. On both days, frequently sampled blood glucose levels were measured at the DirecNet central laboratory. Insulin doses were similar on both days. During exercise, plasma glucose levels fell in almost all subjects; 11 (22%) developed hypoglycemia. Mean glucose level from 10 pm to 6 am was lower on the exercise day than on the sedentary day (131 vs 154 mg/dL; P=.003). Hypoglycemia developed overnight more often on the exercise nights than on the sedentary nights (P=.009), occurring on the exercise night only in 13 (26%), on the sedentary night only in 3 (6%), on both nights in 11 (22%), and on neither night in 23 (46%). Hypoglycemia was unusual on the sedentary night if the pre-bedtime snack glucose level was>130 mg/dL. These findings indicate that overnight hypoglycemia after exercise is common in children with T1DM and support the importance of modifying diabetes management after afternoon exercise to reduce the risk of hypoglycemia.

Humans

Male

Circadian Rhythm - physiology

Diabetes Mellitus, Type 1 - complications

Cross-Over Studies

Hypoglycemia - etiology

Diabetes Mellitus, Type 1 - blood

Adolescent

Female

Exercise - physiology

Blood Glucose - metabolism

Child

Cohort Studies

Details

Title: Subtitle: Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitus
Creators: Eva Tsalikian - DirectNet Coordinating Center, Jaeb Center for Health Research, Tampa, Florida 33647, USA. direcnet@jaeb.org
Nelly Mauras
Roy W Beck
William V Tamborlane
Kathleen F Janz
H Peter Chase
Tim Wysocki
Stuart A Weinzimer
Bruce A Buckingham
Craig Kollman
Dongyuan Xing
Katrina J Ruedy
Diabetes Research In Children Network Direcnet Study Group
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.147(4), pp.528-534
DOI: 10.1016/j.jpeds.2005.04.065
PMID: 16227041
PMCID: PMC2258153
NLM abbreviation: J Pediatr
ISSN: 0022-3476
eISSN: 1097-6833
Grant note: U10 HD041890 / NICHD NIH HHS M01 RR06022 / NCRR NIH HHS U10 HD041915-01 / NICHD NIH HHS U10 HD041906 / NICHD NIH HHS M01 RR00059 / NCRR NIH HHS U10 HD041919-01 / NICHD NIH HHS M01 RR000069 / NCRR NIH HHS U10 HD041918-01 / NICHD NIH HHS M01 RR000070 / NCRR NIH HHS M01 RR006022 / NCRR NIH HHS HD041890 / NICHD NIH HHS U10 HD041918 / NICHD NIH HHS U10 HD041906-01 / NICHD NIH HHS U10 HD041919 / NICHD NIH HHS U10 HD041908-01 / NICHD NIH HHS U10 HD041915 / NICHD NIH HHS M01 RR00069 / NCRR NIH HHS U01 HD041890-01 / NICHD NIH HHS M01 RR00070-41 / NCRR NIH HHS M01 RR000059 / NCRR NIH HHS U10 HD041908 / NICHD NIH HHS U01 HD041890 / NICHD NIH HHS
Language: English
Date published: 10/2005
Academic Unit: Stead Family Department of Pediatrics; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology
Record Identifier: 9984093360102771

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