Impact of formulation on solid oxygen-entrapping materials to overcome tumor hypoxia

Megan K. Mcgovern; Emily Witt; Ashley C. Rhodes; Jinhee Kim; Vivian R. Feig; Jianling Bi; Arielle B. Cafi; Sam Hatfield; Ikenna Nwosu; James D. Byrne

doi:10.1002/jbm.a.37671

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Impact of formulation on solid oxygen-entrapping materials to overcome tumor hypoxia

Journal article

Open access

Peer reviewed

Impact of formulation on solid oxygen-entrapping materials to overcome tumor hypoxia

Megan K. Mcgovern, Emily Witt, Ashley C. Rhodes, Jinhee Kim, Vivian R. Feig, Jianling Bi, Arielle B. Cafi, Sam Hatfield, Ikenna Nwosu and James D. Byrne

Journal of biomedical materials research. Part A, Vol.112(6), pp.931-940

06/2024

DOI: 10.1002/jbm.a.37671

PMCID: PMC10984782

PMID: 38230545

Appears in UI Libraries Support Open Access

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Abstract

Tumor hypoxia, resulting from rapid tumor growth and aberrant vascular proliferation, exacerbates tumor aggressiveness and resistance to treatments like radiation and chemotherapy. To increase tumor oxygenation, we developed solid oxygen gas-entrapping materials (O2-GeMs), which were modeled after clinical brachytherapy implants, for direct tumor implantation. The objective of this study was to investigate the impact different formulations of solid O2-GeMs have on the entrapment and delivery of oxygen. Using a Parr reactor, we fabricated solid O2-GeMs using carbohydrate-based formulations used in the confectionary industry. In evaluating solid O2-GeMs manufactured from different sugars, the sucrose-containing formulation exhibited the highest oxygen concentration at 1 mg/g, as well as the fastest dissolution rate. The addition of a surface coating to the solid O2-GeMs, especially polycaprolactone, effectively prolonged the dissolution of the solid O2-GeMs. In vivo evaluation confirmed robust insertion and positioning of O2-GeMs in a malignant peripheral nerve sheath tumor, highlighting potential clinical applications.

interventional oncology

intratumoral oxygen

partial pressure

therapy resistance

UIOWA OA Agreement

Details

Title: Subtitle: Impact of formulation on solid oxygen-entrapping materials to overcome tumor hypoxia
Creators: Megan K. Mcgovern - Univ Iowa, Dept Radiat Oncol, 200 Hawkins Dr, Iowa City, IA 52242 USA
Emily Witt - University of Iowa
Ashley C. Rhodes - University of Iowa
Jinhee Kim - University of Toronto
Vivian R. Feig - Brigham and Women's Hospital
Jianling Bi - University of Iowa
Arielle B. Cafi - University of Iowa
Sam Hatfield - Univ Iowa, Dept Radiat Oncol, 200 Hawkins Dr, Iowa City, IA 52242 USA
Ikenna Nwosu - University of Iowa
James D. Byrne - University of Iowa
Resource Type: Journal article
Publication Details: Journal of biomedical materials research. Part A, Vol.112(6), pp.931-940
DOI: 10.1002/jbm.a.37671
PMID: 38230545
PMCID: PMC10984782
NLM abbreviation: J Biomed Mater Res A
ISSN: 1549-3296
eISSN: 1552-4965
Publisher: Wiley
Number of pages: 10
Grant note: National Institutes of Health. Grant Number: 1K08CA276908 Prostate Cancer Foundation U.S. Department of Defense. Grant Number: W81XWH-20-1-0225 V Foundation for Cancer Research Dr. Ralph and Marian Falk Medical Research Trust American Cancer Society - Institutional Research Grant. Grant Number: 21-141-46
Language: English
Electronic publication date: 01/17/2024
Date published: 06/2024
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiation Oncology
Record Identifier: 9984555542702771

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