Impact of high neutrophil‐to‐lymphocyte ratio on survival in hospitalized cancer patients with COVID ‐19

Fernando A. Díaz-Couselo; Santiago Flagel; Carla Nicolini; Sebastián Halac; Natalia Manzano; Marina Aguirre; Juan Rébora; Sandra Valle; Laura Noro; Chirayu Mohindroo; Florencia McAllister; Marcelo Zylberman

doi:10.1002/cam4.5426

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Impact of high neutrophil‐to‐lymphocyte ratio on survival in hospitalized cancer patients with COVID ‐19

Journal article

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Impact of high neutrophil‐to‐lymphocyte ratio on survival in hospitalized cancer patients with COVID ‐19

Fernando A. Díaz-Couselo, Santiago Flagel, Carla Nicolini, Sebastián Halac, Natalia Manzano, Marina Aguirre, Juan Rébora, Sandra Valle, Laura Noro, Chirayu Mohindroo, …

Cancer medicine (Malden, MA), Vol.12(6), pp.7164-7169

03/2023

DOI: 10.1002/cam4.5426

PMID: 36372937

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Abstract

Neutrophil‐to‐lymphocyte ratio (NLR) has been studied as a prognostic factor for mortality in COVID‐19 patients. Our study aimed to evaluate the association between NLR at COVID‐19 diagnosis and survival during the following 90 days in hospitalized patients with solid cancer. Between May 2020 and June 2021, 120 patients were included in a retrospective cohort study. Univariable analysis showed patients with an NLR > 8.3 were associated with an increased risk of death (HR: 4.34; 95% CI: 1.74–10.84) compared to patients with NLR < 3.82 and with NLR ≥3.82 and ≤8.30 (HR: 2.89; 95% CI: 1.32–6.36). Furthermore, on multivariable analysis, NLR > 8.30 independently correlated with increased mortality. In patients with solid malignancies with COVID‐19, an NLR > 8.3 is associated with an increased risk of death.

Details

Title: Subtitle: Impact of high neutrophil‐to‐lymphocyte ratio on survival in hospitalized cancer patients with COVID ‐19
Creators: Fernando A. Díaz-Couselo - Instituto Alexander Fleming
Santiago Flagel - Instituto Alexander Fleming
Carla Nicolini - Instituto Alexander Fleming
Sebastián Halac - Instituto Alexander Fleming
Natalia Manzano - Instituto Alexander Fleming
Marina Aguirre - Instituto Alexander Fleming
Juan Rébora - Instituto Alexander Fleming
Sandra Valle - Instituto Alexander Fleming
Laura Noro - Instituto Alexander Fleming
Chirayu Mohindroo - The University of Texas MD Anderson Cancer Center
Florencia McAllister - The University of Texas MD Anderson Cancer Center
Marcelo Zylberman - Instituto Alexander Fleming
Resource Type: Journal article
Publication Details: Cancer medicine (Malden, MA), Vol.12(6), pp.7164-7169
DOI: 10.1002/cam4.5426
PMID: 36372937
NLM abbreviation: Cancer Med
ISSN: 2045-7634
eISSN: 2045-7634
Number of pages: 6
Language: English
Date published: 03/2023
Academic Unit: Internal Medicine
Record Identifier: 9985178655602771

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